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Lactose

Lactose Structure
CAS No.
63-42-3
Chemical Name:
Lactose
Synonyms
D-LACTOSE;MILK SUGAR;BETA-LACTOSE;LACTIN;Lactosum;LACTOBIOSE;D-Lactose Anhydrous;Lactosum , anhydrous;Lactose (anhydrous) CRS;4-O-BETA-GALACTOPYRANOSYL-D-GLUCOSE
CBNumber:
CB8710411
Molecular Formula:
C12H22O11
Molecular Weight:
342.3
MOL File:
63-42-3.mol
Modify Date:
2024/8/14 18:30:21
Request For Quotation

Lactose Properties

Melting point 222.8°C
Boiling point 397.76°C (rough estimate)
Density 1.5300
refractive index 1.5376 (estimate)
storage temp. 2-8°C
solubility Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent).
form Powder
pka 12.39±0.20(Predicted)
color White to Off-white
Odor Mildly sweet taste.
Water Solubility 5-10 g/100 mL at 20 ºC
BRN 93796
Stability Stable. Incompatible with strong oxidizing agents.
LogP -3.391 (est)
CAS DataBase Reference 63-42-3(CAS DataBase Reference)
NIST Chemistry Reference D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3)
EPA Substance Registry System Lactose (63-42-3)

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  2
RTECS  OD9625000
TSCA  Yes
HS Code  17021100

Lactose price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1025 Lactose, Anhydrous Pharmaceutical Secondary Standard; Certified Reference Material 63-42-3 1G ₹9983.25 2022-06-14 Buy
Sigma-Aldrich 17814 Lactose tested according to Ph. Eur. 63-42-3 1KG ₹15975.75 2022-06-14 Buy
Sigma-Aldrich(India) 17814 Lactose tested according to Ph. Eur. 63-42-3 1KG ₹15975.75 2022-06-14 Buy
ALFA India ALF-J66376-A1 Thermo Scientific™ D-Lactose 63-42-3 1kg ₹13047 2022-05-26 Buy
ALFA India ALF-J66376-36 Thermo Scientific™ D-Lactose 63-42-3 500g ₹6677 2022-05-26 Buy
Product number Packaging Price Buy
PHR1025 1G ₹9983.25 Buy
17814 1KG ₹15975.75 Buy
17814 1KG ₹15975.75 Buy
ALF-J66376-A1 1kg ₹13047 Buy
ALF-J66376-36 500g ₹6677 Buy

Lactose Chemical Properties,Uses,Production

Chemical Properties

Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70–80% anhydrous b-lactose and 20–30% anhydrous a-lactose.

Uses

Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent.

Definition

A sugar found in milk. It is a disaccharide composed of glucose and galactose units.

Production Methods

There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Air & Water Reactions

Water soluble.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic.

Pharmaceutical Applications

Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections.

Safety

Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms.

storage

Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day.
Lactose anhydrous should be stored in a well-closed container in a cool, dry place.

Purification Methods

-Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.]

Incompatibilities

Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation.
Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups.
Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Lactose Preparation Products And Raw materials

Raw materials

MILK Α-protein Whey

Preparation Products

Whev’redliced lactose Abamectin Lactulose Pepsin L-carnitine
LACTITOL Whey CARAMEL Whey saIts thyroid powder
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Lactose Suppliers

Global( 573)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Lactose (India) Limited. +91-022-24117032 +91-7045349754 Mumbai, India 2 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Prachin Chemical +91-7922821740 +91-9825015645 Gujarat, India 21 58 Inquiry
Prakash Chemicals Agencies +91-8511140657 Gujarat, India 106 58 Inquiry
OCEAN TRADING CORPORATION +91(22) 24921669 New Delhi, India 6211 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Capri Enterprise 08046061012 Mumbai, India 3 58 Inquiry
Supplier Advantage
Lactose (India) Limited. 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
Prachin Chemical 58
Prakash Chemicals Agencies 58
OCEAN TRADING CORPORATION 58
CHEMSWORTH 30
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Alfa Aesar 58
Capri Enterprise 58

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ANHYDROUSLACTOSE,NF LACTOSE,ANHYDROUS,FCC (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-oxane-3,4,5-triol D-Glucose, 4-O-b-D-galactopyranosyl (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol D-Lactose ,98% Lactose,Lactosum anhydricum Anhydrous Lactose (100 mg) 4-o-beta-d-galactopyranosyl-d-glucos 4-(beta-D-Galactosido)-D-glucose Lactosum anhydricum SynonyMs: 4-(beta-D-Galactosido)-D-glucose, D-(+)-Lactose LactoseHydrate D-(+)-LACTOSE (ANHYDROUS) EP STANDARD LACTOSE ANHYDROUS, PH EUR SUGAR MILK 4-(B-D-GALACTOSIDO)-D-GLUCOSE D-(+)-LACTOSE LACTOSE : 4-(beta-D-Galactosido)-D-glucose, D-(+)-Lactose saccharumlactin Saccharum lactin Osmolactan lactose,anhydrous Galactinum Aletobiose Lactosum , anhydrous, AR,98% Lactose Manufacturer Carvedilol-N-&beta Lactosum , anhydrous, Ph Eur,USP,NF,JP Anhydrous Lactose for Identification RS D-Glucose, 4-O-β-D-galactopyranosyl- (3R,4R,5S,6R)-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal hot selling Lactose Lactose USP/EP/BP D-Lactose Lactosum , anhydrous 4-O-β-D-galactopyranosyl-D-glucopyranose (lactose) Sweeteners Lactose Monohydrate Food Grade D-Lactose CAS?63-42-3?Lactose medicinal lactose Lactose Fast Flo Pharma Grade Anhydrous Lactose (1356676) Lactose Joyce Top Supplier of Lactose Lactosum , anhydrous MILK SUGAR BETA-LACTOSE D-LACTOSE LACTIN D-Lactose Anhydrous LACTOBIOSE Lactose (anhydrous) CRS Lactosum D-Glucose, 4-O-.beta.-D-galactopyranosyl- 4-O-BETA-GALACTOPYRANOSYL-D-GLUCOSE α-D-(+)-Lactose Lactose 200 Mesh