Anagrelide hydrochloride
- CAS No.
- 58579-51-4
- Chemical Name:
- Anagrelide hydrochloride
- Synonyms
- ANAGRELIDE HCL;AGRYLIN;RL 603;Xagrid;Agrelin;BL-4162A;Agryline,HCl;BMY-26538-01;TroMboreductin;Xagrid hydrochloride
- CBNumber:
- CB8722913
- Molecular Formula:
- C10H8Cl3N3O
- Molecular Weight:
- 292.55
- MOL File:
- 58579-51-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:50
| Melting point | >280°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble1mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 58579-51-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H361d-H413 | |||||||||
| Precautionary statements | P202-P273-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Anagrelide hydrochloride price More Price(2)
Anagrelide hydrochloride Chemical Properties,Uses,Production
Description
Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.
Chemical Properties
Off-White Powder
Definition
ChEBI: The hydrochloride salt of anagrelide.
General Description
Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds.
Biological Activity
Potent type III phosphodiesterase (PDE3) inhibitor (IC 50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.
Anagrelide hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Zydus Lifesciences Ltd. | +91-0265-2315243 +91-6358895661 | Gujarat, India | 89 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TORRENT PHARMACEUTICALS LTD | +91-79-26599000 | New Delhi, India | 36 | 58 | Inquiry |
| CADILA HEALTHCARE LTD | +91 2718 225001 | New Delhi, India | 110 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
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