Anagrelide hydrochloride
Anagrelide hydrochloride
- CAS:
- 58579-51-4
- MF:
- C10H8Cl3N3O
- MW:
- 292.55
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Company Type
Properties
- Melting point:
- >280°C
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble1mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H351-H361d-H413
- Precautionary statements
- P202-P273-P280-P308+P313-P405-P501
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
Use
Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.
4 India supplier list of "Anagrelide hydrochloride "
- Product Name:Anagrelide hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Anagrelidehydrochloride
- Products Intro:Brand:sigma aldrich | Product Number:SML0846 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: INDIA
- Product Name:AnagrelideHydrochloride
- Products Intro:Brand:pharmaffiliates | Product Number:PA2818000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Anagrelide hydrochloride
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:AnagrelideHydrochloride
- Products Intro:Brand:synzeal | Product Number:176543591
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Anagrelide Hydrochloride
- Products Intro:Purity: More Than 99% | Package: 1g
- Company Type: Trader
- Country/Region: CHINA
$0.00/ 1g