Anagrelide hydrochloride manufacturers and suppliers in india

Anagrelide hydrochloride

Properties

Melting point:: >280°C

storage temp.: 2-8°C

solubility: DMSO: soluble1mg/mL, clear (warmed)

form: powder

color: white to beige

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H351-H361d-H413

Precautionary statements: P202-P273-P280-P308+P313-P405-P501

Hazard Codes: Xn

Risk Statements: 22-36/37/38

Safety Statements: 26

WGK Germany: 3

Use

Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.