etomidoline

CAS No.: 21590-92-1

Chemical Name:: etomidoline

Synonyms: Nonspa;K 2680;Smedolin;Amidoline;etomidoline;Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI);2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one;2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one;1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-

CBNumber:: CB8896360

Molecular Formula:: C23H29N3O2

Molecular Weight:: 379.5

MOL File:: 21590-92-1.mol

Modify Date:: 2023/5/4 17:34:35

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etomidoline Properties

Melting point	106-107°
Boiling point	507.34°C (rough estimate)
Density	1.1315 (rough estimate)
refractive index	1.6500 (estimate)
pka	8.75±0.10(Predicted)

SAFETY

Risk and Safety Statements

Toxicity	LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971)

etomidoline Chemical Properties,Uses,Production

Originator

Smedolin,Yamanouchi,Japan,1976

Manufacturing Process

31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol) are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution 5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added and the resulted mixture is heated at 70°C for 1 hour, and then poured into an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)- isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to 104°C) is obtained as a byproduct with the above compound. This latter compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.

Therapeutic Function

Muscle relaxant

etomidoline Preparation Products And Raw materials

Raw materials

Iodoethane Sodium hydride

Preparation Products

etomidoline Suppliers

Global( 3)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Lanospharma Laboratories Co.,Ltd	13440048448	China	6343	56	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24017	58	Inquiry

Supplier	Advantage
TargetMol Chemicals Inc.	58
Lanospharma Laboratories Co.,Ltd	56
TargetMol Chemicals Inc.	58

21590-92-1(etomidoline)Related Search:

4-[2-(DIMETHYLAMINO)ETHOXY]ANILINE 97 4-(2-piperidinoethoxy)aniline omidoline 4-(2-(DIETHYLAMINO)ETHOXY)ANILINE, 97 etomidoline

etomidoline 1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]- Amidoline K 2680 Nonspa Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI) Smedolin 2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one 2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one 21590-92-1