Amineptine
- CAS No.
- 57574-09-1
- Chemical Name:
- Amineptine
- Synonyms
- amineptin;Survector;amineptine;ONNOFKFOZAJDHT-UHFFFAOYSA-N;7-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid;Heptanoic acid, 7-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)aMino]-
- CBNumber:
- CB8897347
- Molecular Formula:
- C22H27NO2
- Molecular Weight:
- 337.46
- MOL File:
- 57574-09-1.mol
- Modify Date:
- 2023/5/15 10:44:02
| Melting point | 209 °C |
|---|---|
| Boiling point | 509.9±50.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.75±0.10(Predicted) |
| color | White to Pale Yellow |
| NIST Chemistry Reference | Amineptine(57574-09-1) |
Amineptine Chemical Properties,Uses,Production
Uses
Amineptine is used as an atypical tricyclic antidepressant. Amineptine selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine.
Definition
ChEBI: A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it w s never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.
Enzyme inhibitor
This synthetic dopamine reuptake inhibitor (FW = 338.47 g/mol; CAS 57574-09-1), also known by the trade names Survector?, Maneon?, Directim?, Neolior?, Provector?, and Viaspera? as well as its IUPAC name, 7-[(10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)amino]heptanoic acid, significantly reduces the effect of 6-hydroxy-dopamine on brain dopamine, increases striatal homovanillic acid concentrations, and shows cross-tolerance. Despite these amphetamine-like properties, amineptine does not alter brain noradrenaline or acetylcholine concentrations, suggesting amineptine is a new type of antidepressant with a brain biochemical profile differing from that of other drugs used in depressive disorders. Amineptine is also a norepinephrine reuptake inhibitor. This agent is also ineffective in reducing amphetamine withdrawal symptoms or craving. Amineptine failed to secure FDA approval and is not a duly authorized drug in the U.S.
Amineptine Preparation Products And Raw materials
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