Phosphinothricin
- CAS No.
- 51276-47-2
- Chemical Name:
- Phosphinothricin
- Synonyms
- C05042;HOE-866;HOE-35956;Glufosite;Phosphinothricin;2'-Anhydrouridine;13C,2H3]-Glufosinate;IAJOBQBIJHVGMQ-UHFFFAOYSA-N;Phosphinothricin ammonium salt;2-amino-4-(hydroxymethylphosphinyl)butyric acid
- CBNumber:
- CB8918965
- Molecular Formula:
- C5H12NO4P
- Molecular Weight:
- 181.13
- MOL File:
- 51276-47-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/8 15:53:14
| Melting point | 229-231° (dec) |
|---|---|
| Boiling point | 519.1±45.0 °C(Predicted) |
| Density | 1.378±0.06 g/cm3(Predicted) |
| solubility | Aqueous Acid (Slightly), Methanol (Very Slightly, Sonicated), Water (Slightly) |
| form | Solid |
| pka | 2.22±0.10(Predicted) |
| color | White to Light Beige |
| Stability | Hygroscopic |
| LogP | -0.750 (est) |
| EPA Substance Registry System | Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)- (51276-47-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H302-H312-H373 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P260-P314-P501-P280-P302+P352-P312-P322-P363-P501 |
Phosphinothricin Chemical Properties,Uses,Production
Enzyme inhibitor
This dephospho transition-state analogue (FW = 177.10 g/mol; CAS 51276- 47-2) is naturally occurring glutamate analogue, first isolated from Streptomyces viridochromogenes. Phosphonothricin is a slow, tight-binding inhibitor of glutamine synthetase that binds at the glutamate binding site and stabilizes the flap of a glutamyl residue in a position blocking glutamate entry into the active site, thereby trapping the inhibitor on the enzyme. Phosphinothricin undergoes an ATP-dependent phosphorylation. Note: Phosphinothricin is a component of the antibiotics bialaphos and phosalacine. The monoammonium salt of the racemic compound, also called glufosinate-ammonium, is a post-emergent herbicide.
Metabolic pathway
When 14C-phosphinothricin [homoalanin-4-yl- (methyl)phosphinic acid] is incubated in the cell suspension cultures of soybean, wheat, and maize, in maize cells which take up to 50% of the applied radioactivity, four different metabolites are detected which are identified as 4-methylphosphinico-2-oxo- butyric acid, 4-methylphosphinico-2-hydroxybutyric acid, 4-methylphosphinicobutyric acid, and 3- methylphosphinicopropionic acid. In soybean and wheat cultures, 10 and 6% of the applied radioactivity is taken up, respectively. In soybean, only one metabolite, 3-methylphosphinicopropionic acid, is detected, whereas in wheat, 4-methyl- phosphinicobutyric acid is additionally present.
Phosphinothricin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| AS WATER CO., LTD. | +86-18994963526 +8618994963526 | United Kingdom | 176 | 58 | Inquiry |