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CEFTRIAXONE

CEFTRIAXONE Structure
CAS No.
73384-59-5
Chemical Name:
CEFTRIAXONE
Synonyms
CEFTRIAZONE;Ceftriazone sodiuM;Ceftriaxone Sodium Ep Impurity A;Rocefin;Biotrakson;Rocephin(e);CEFTRIAXONE;CEFATRIAXONE;Cefatriaxone From;Antibiotic Ro-13-9904
CBNumber:
CB9114533
Molecular Formula:
C18H18N8O7S3
Molecular Weight:
554.58
MOL File:
73384-59-5.mol
Modify Date:
2024/8/1 23:06:22
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CEFTRIAXONE Properties

Melting point 155 °C
Density 1.96±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMSO (Slightly), Methanol (Slightly)
pka pKa –3.2±0.6 (Uncertain);–1.8±0.2 (Uncertain);2.57±0.50 (Uncertain);2.90±0.50 (Uncertain);8.03±0.40 (Uncertain)
form Solid
color Off-White to Pale Yellow
Stability Hygroscopic
CAS DataBase Reference 73384-59-5(CAS DataBase Reference)
EPA Substance Registry System Ceftriaxone (73384-59-5)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H317-H334-H319-H335
Precautionary statements  P261-P285-P304+P341-P342+P311-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  22-24-37-45
HS Code  29349990

CEFTRIAXONE Chemical Properties,Uses,Production

Description

Ceftriaxone has the same C-7 side-chain moiety as cefotaxime and ceftizoxime, but the C-3 side chain consists of a metabolically stable and activating thiotriazinedione in place of the normal acetyl group. The C-3 side chain is sufficiently acidic that at normal pH, it forms an enolic sodium salt; thus, the commercial product is a disodium salt.

Uses

Ceftriaxone is an antibacterial, a third-generation cephalosporin.

Definition

ChEBI: A cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.

Antimicrobial activity

Most β-lactamase-producing enterobacteria are highly susceptible, as are streptococci (but not enterococci) and fastidious Gram-negative bacilli, although brucellae are less sensitive (MIC 0.25–2 mg/L). Treatment failure has been reported in tularemia. Ps. aeruginosa, mycoplasmas, mycobacteria and L. monocytogenes are resistant.

Acquired resistance

Ceftriaxone is hydrolyzed by some chromosomal enzymes, including those of Enterobacter spp. and B. fragilis. Derepression of chromosomal β-lactamase production can cause resistance in some species of Gram-negative bacilli in vitro and has been observed in patients.

Clinical Use

Uses of Ceftriaxone are similar to those of cefotaxime, the long half-life offering the advantage of once-daily administration. It is used in the treatment of acute bacterial meningitis and as an alternative to rifampicin (rifampin) in the prophylaxis of meningococcal disease.

Side effects

Reactions are those common to other cephalosporins. Mention has been made of thrombocytopenia, thrombocytosis, leukopenia, eosinophilia abdominal pain, phlebitis, rash, fever and increased values in liver function tests. Diarrhea is common and suppression of the aerobic and anaerobic fecal flora has been associated with the appearance of resistant bacteria and yeasts.
Biliary pseudolithiasis due to concretions of insoluble calcium salt has been described in adults but principally in children. The precipitates can be detected in a high proportion of patients by ultrasonography and can occasionally cause pain, but resolve on cessation of treatment. Ceftriaxone is better avoided in patients with pre-existing biliary disease, but the principal hazard appears to be misdiagnosis of gallbladder disease and unnecessary surgery.

CEFTRIAXONE Preparation Products And Raw materials

Raw materials

thiosemicarbazide 7-ACT Dimethyl oxalate Silicon urea naptho[1’,8a’,8’:bc]-bicyclo[3.1.0]hex-2-ene
Silicon tetrahydride Double sodium salt Glutamic acid PIVALAMIDE Thiotriazinone
Chloroacetyl chloride Benzaldehyde Methylhydrazine sulfate Methylhydrazine Potassium thiocyanate
Activ Ester CARBOXYLIC ACID Formic acid
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Preparation Products

CEFTRIAXONE Suppliers

Global( 159)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
PROTECH TELELINKS +91-8571891912 +91-9855060837 Himachal Pradesh, India 62 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Shinepro Life Sciences Private Limited 08048981934 Haryana, India 3 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Hebei Lingding Biotechnology Co., Ltd. +86-18031140164 +86-19933155420 China 452 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +8613288715578 China 12459 58 Inquiry
Hebei Guanlang Biotechnology Co,.LTD +86-19930503253; +8619930503252 China 5835 58 Inquiry
Shaanxi TNJONE Pharmaceutical Co., Ltd +8618740459177 China 1142 58 Inquiry
Supplier Advantage
PROTECH TELELINKS 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Shinepro Life Sciences Private Limited 58
Pharma Affiliates 58
Hebei Lingding Biotechnology Co., Ltd. 58
Hebei Mojin Biotechnology Co., Ltd 58
Hebei Guanlang Biotechnology Co,.LTD 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 58

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5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, (6R,7R)- Biotrakson Rocefin Rocephin(e) (6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Ceftriaxone sodium 2,4(triazin-3-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium 7-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-3-{[(2-METHYL-5,6-DIOXO-1,2,5,6-TETRAHYDRO-1,2,4-TRIAZIN-3-YL)SULFANYL]METHYL}-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLI C ACID 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-,(6R,7R)- CEFATRIAXONE CEFTRIAXONE Ceftriazone sodium(Sterile) (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Antibiotic Ro-13-9904 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, [6R-[6α,7β(Z)]]- Cefatriaxone From (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid CEFTRIAXONE USP/EP/BP CeftriaxoneQ: What is Ceftriaxone Q: What is the CAS Number of Ceftriaxone Q: What is the storage condition of Ceftriaxone Ceftriaxone PDR F Injection 1 g CEFTRIAZONE Ceftriazone sodiuM Ceftriaxone Sodium Ep Impurity A Butanoicacid,4-bromo-8-oxo-,ethylester Ceftriaxone free acid 73384-59-5 C18H18N8O7S3 C18H18N8O7S3Na C18H16N8O7S32Na