Succimer
- CAS No.
- 304-55-2
- Chemical Name:
- Succimer
- Synonyms
- DMSA;MESO-2,3-DIMERCAPTOSUCCINIC ACID;chemet;dim-sa;uccimer;ro1-7977;SUCCIMER;AI312104;MESO-DMSA;AI3 12104
- CBNumber:
- CB9142563
- Molecular Formula:
- C4H6O4S2
- Molecular Weight:
- 182.22
- MOL File:
- 304-55-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/28 19:59:05
| Melting point | 196-198 °C (dec.)(lit.) |
|---|---|
| Boiling point | 285.62°C (rough estimate) |
| Density | 1.439 (estimate) |
| refractive index | 1.5220 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO (Sparingly), Methanol (Slightly, Heated) |
| form | Powder |
| pka | pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C) |
| color | White to off-white |
| Water Solubility | Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear). |
| Merck | 14,8865 |
| BRN | 1725150 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | ACTRVOBWPAIOHC-XIXRPRMCSA-N |
| CAS DataBase Reference | 304-55-2(CAS DataBase Reference) |
| EPA Substance Registry System | Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H361 | |||||||||
| Precautionary statements | P201-P261-P280-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WM7650000 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29309090 | |||||||||
| Toxicity | LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi) | |||||||||
| NFPA 704 |
|
Succimer price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D7881 | meso-2,3-Dimercaptosuccinic acid ~98% | 304-55-2 | 1G | ₹2143.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7881 | meso-2,3-Dimercaptosuccinic acid ~98% | 304-55-2 | 5G | ₹7198.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7881 | meso-2,3-Dimercaptosuccinic acid ~98% | 304-55-2 | 25G | ₹22981.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7881 | meso-2,3-Dimercaptosuccinic acid ~98% | 304-55-2 | 50G | ₹34455.98 | 2022-06-14 | Buy |
| ALFA India | ALF-A17909-06 | meso-2,3-Dimercaptosuccinic acid, 97% | 304-55-2 | 5g | ₹4945 | 2022-05-26 | Buy |
Succimer Chemical Properties,Uses,Production
Description
Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.
Chemical Properties
white or off-white powder
Definition
ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
Pharmaceutical Applications
Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant
smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name
is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are
two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment
of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been
successfully used for the treatment of heavy-metal poisoning.
Purification Methods
Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]
Succimer Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9262 | 55 | Inquiry |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | China | 1080 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| A.J Chemicals | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Triveni chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| CHEMSWORTH | 30 |
| Hangzhou FandaChem Co.,Ltd. | 55 |
| Shanghai Worldyang Chemical Co.,Ltd. | 58 |
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