6-Aminopyridine-3-carboxamide
- CAS No.
- 329-89-5
- Chemical Name:
- 6-Aminopyridine-3-carboxamide
- Synonyms
- 6-AN;6-ANA;U-8774;fda0121;SR-4388;FDA 0121;nsc21206;NSC 21206;NSC-13128;BRN 2034522
- CBNumber:
- CB9224555
- Molecular Formula:
- C6H7N3O
- Molecular Weight:
- 137.14
- MOL File:
- 329-89-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:12
| Melting point | 245-248 °C (lit.) |
|---|---|
| Boiling point | 251.97°C (rough estimate) |
| Density | 1.2620 (rough estimate) |
| refractive index | 1.6910 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | insoluble in H2O; insoluble in EtOH; ≥13.7 mg/mL in DMSO |
| form | powder to crystal |
| pka | 15.66±0.50(Predicted) |
| color | White to Light yellow |
| Water Solubility | Soluble in Dimethyl sulfoxide (DMSO). Insoluble in water. |
| BRN | 116042 |
| CAS DataBase Reference | 329-89-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Nicotinamide, 6-amino-(329-89-5) |
| EPA Substance Registry System | 6-Aminonicotinamide (329-89-5) |
6-Aminopyridine-3-carboxamide price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A68203 | 6-Aminonicotinamide 99% | 329-89-5 | 1G | ₹4178.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A68203 | 6-Aminonicotinamide 99% | 329-89-5 | 5G | ₹34802.38 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A0986 | 6-Aminonicotinamide | 329-89-5 | 1G | ₹6700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A0986 | 6-Aminonicotinamide | 329-89-5 | 5G | ₹27400 | 2022-05-26 | Buy |
| ottokemi | A 8996 | 6-Aminonicotinamide, 99% | 329-89-5 | 1gm | ₹9603 | 2022-05-26 | Buy |
6-Aminopyridine-3-carboxamide Chemical Properties,Uses,Production
Uses
antineoplastic, apoptosis inducer
Definition
ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.
General Description
White crystalline solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
An amine and amide. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-Aminopyridine-3-carboxamide emits toxic fumes of NOx.
Fire Hazard
Flash point data for 6-Aminopyridine-3-carboxamide are not available; however, 6-Aminopyridine-3-carboxamide is probably combustible.
6-Aminopyridine-3-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13164 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |