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Estazolam

CAS No.: 29975-16-4

Chemical Name:: Estazolam

Synonyms: ProSom;8-CHLORO-6-PHENYL-4H-[1,2,4]-TRIAZOLO[4,3-A][1,4]BENZODIAZEPINE;Cannoc;D 40TA;d-40ta;u33737;Nemurel;Julodin;Esilgan;Eurodin

CBNumber:: CB9247411

Molecular Formula:: C16H11ClN4

Molecular Weight:: 294.74

MOL File:: 29975-16-4.mol

Modify Date:: 2023/6/8 9:02:16

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Estazolam Properties

Melting point	228-229°
Boiling point	448.04°C (rough estimate)
Density	1.2294 (rough estimate)
refractive index	1.6110 (estimate)
Flash point	11 °C
storage temp.	2-8°C
solubility	DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form	A crystalline solid
pka	pKa 2.84(H2O) (Uncertain)
CAS DataBase Reference	29975-16-4(CAS DataBase Reference)
IARC	3 (Vol. 66) 1996
NIST Chemistry Reference	Estazolam(29975-16-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS06,GHS08

Signal word

Danger

Hazard statements

H225-H301+H311+H331-H370

Precautionary statements

P210-P260-P280-P301+P310-P311

Hazard Codes

Xi,T,F

Risk Statements

36/37/38-39/23/24/25-23/24/25-11

Safety Statements

36/37/39-45-36/37-16-7

RIDADR

3249

WGK Germany

RTECS

XZ5473500

HazardClass

6.1(b)

PackingGroup

III

HS Code

2933910000

Toxicity

LD50 orally in male mice, rats and rabbits: 740, 3200, 300 mg/kg (Yokotani)

NFPA 704

	0
2		0

Estazolam Chemical Properties,Uses,Production

Uses

A benzodiazepine derivative possessing anxiolytic, anticonvulsant, and muscle relaxant properties. It is commonly prescribed to treat short-term insomnia. Controlled Substance.

Definition

ChEBI: A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term ma agement of insomnia.

Estazolam Preparation Products And Raw materials

Raw materials

4-Chloronitrobenzene phenylacetonitrile Triethyl orthoformate Chloroacetyl chloride Hexamethylenetetramine

Formylhydrazine 2-(2-ACETYLHYDRAZINO)-7-CHLORO-5-PHENYL-3H-1,4-BENZODIAZEPINE N-desmethyl-N(4)-desoxychlordiazepoxide FORMAMIDINE HYDROCHLORIDE

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Preparation Products

29975-16-4(Estazolam)Related Search:

Chlorodimethylphenylsilane 1H-Benzotriazole tert-Butylchlorodiphenylsilane PHENYL VALERATE Phenylhydrazine

Ribavirin CHLOROPHENYLSILANE 97 1,2,3-1H-Triazole Epichlorohydrin Triphenylmethyl Chloride

1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE Difluorochloromethane Chloroacetic acid 4-HYDROXYALPRAZOLAM ALPRAZOLAM-D5

ADINAZOLAM Triazolam Alprazolam

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2,4)triazolo(4,3-a)(1,4)-benzodiazepine,8-chloro-6-phenyl-4h-( 3-a)(1,4)benzodiazepine,8-chloro-6-phenyl-4h-s-triazolo( 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-6-phenyl- 4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl- Julodin Nemurel Nuctalon Somnatrol abbott47631 Abbott-47631 Alprazolam M (hydroxy-)-CH2O Cannoc D 40TA d-40ta Esilgan estazolam100ugpermlinmethanol Eurodin Eurodine 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine u33737 ESTAZOLAM estazolam--dea schedule iv item 8-Chloro- Methanol （test Estazolam, 1.0 mg/mL) Estazolam CIV (100 mg) NSC 290818 Estazolam solution 8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine Estazolam USP/EP/BP ProSom 8-CHLORO-6-PHENYL-4H-[1,2,4]-TRIAZOLO[4,3-A][1,4]BENZODIAZEPINE Estazolam [Controlled Substance Dosulepin Impurity 6 ASZL001 29975-16-4 2029975-16-4 C16H11ClN4 C16H11N4Cl EQ - EZ Analytical Standards Analytical Chromatography Product Catalog Alphabetic Heterocycles Intermediates & Fine Chemicals Pharmaceuticals