Dihydrocholesterol
- CAS No.
- 80-97-7
- Chemical Name:
- Dihydrocholesterol
- Synonyms
- CHOLESTANOL;β-Cholestanol;BETA-CHOLESTANOL;5alpha-Cholestanol;Cholestan-3beta-ol;5A-CHOLESTAN-3B-OL;5α-Cholestan-3β-ol;5ALPHA-CHOLESTAN-3BETA-OL;10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol;NSC 18188
- CBNumber:
- CB9262856
- Molecular Formula:
- C27H48O
- Molecular Weight:
- 388.68
- MOL File:
- 80-97-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 138-142 °C |
|---|---|
| alpha | D22 +24.2° (c = 1.3 in chloroform) |
| Boiling point | 454.32°C (rough estimate) |
| Density | 0.9506 (rough estimate) |
| refractive index | 1.5250 (estimate) |
| storage temp. | -20°C |
| solubility | chloroform: 0.1 g/mL, clear, colorless |
| form | A solid |
| pka | 15.14±0.70(Predicted) |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Insoluble in water. |
| Merck | 14,2200 |
| BRN | 2418594 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| LogP | 10.065 (est) |
| CAS DataBase Reference | 80-97-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Cholestanol(80-97-7) |
| EPA Substance Registry System | Dihydrocholesterol (80-97-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H319-H331-H336-H351-H361d-H372 | |||||||||
| Precautionary statements | P261-P281-P305+P351+P338-P311 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-38-40-48/20/22-67-36/38-20-63 | |||||||||
| Safety Statements | 24/25-36/37-22-26 | |||||||||
| RIDADR | UN 1888 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FZ6350000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2906 13 10 | |||||||||
| NFPA 704 |
|
Dihydrocholesterol price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D6128 | 5α-Cholestan-3β-ol ≥95% | 80-97-7 | 10G | ₹10121.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D6128 | 5α-Cholestan-3β-ol ≥95% | 80-97-7 | 25G | ₹13953.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.41513 | 5α-Cholestan-3ß-ol for synthesis | 80-97-7 | 5G | ₹10330 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 47129 | Cholestanol solution certified reference material, 10?mg/mL in chloroform | 80-97-7 | 1ML | ₹4934.3 | 2022-06-14 | Buy |
| ALFA India | ALF-L08624-14 | 5alpha-Cholestan-3beta-ol, 98% | 80-97-7 | 25g | ₹19700 | 2022-05-26 | Buy |
Dihydrocholesterol Chemical Properties,Uses,Production
Description
Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid . Cholestanol (10 μg/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1β converting enzyme (ICE) and CPP32 proteases. Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum. Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.
Chemical Properties
white powder
Uses
5α-Cholestan-3β-ol is a carbon stanol formed from biohydrogenation of Cholesterol (C432501) in the gut. Studies have also examined the conversion of 5α-Cholestan-3β-ol catalyzed by 3-β-hydroxysteroid dehydrogenase of rat liver.
Definition
ChEBI: A cholestanoid that is (5alpha)-cholestane substituted by a beta-hydroxy group at position 3.
General Description
Cholestanol is a 5α-dihydro derivative of cholesterol. It acts as a marker for cholesterol absorption. Cholestanol is a steroid with 27 carbon atoms.
Purification Methods
Purify 5--cholestan-3-ol via acetylation, crystallisation and de-acetylation, then recrystallisation from EtOH or slightly aqueous EtOH, or MeOH. Its solubility is: 0.5% (MeOH) and 1% (EtOH) at 25o. [Mizutani & Whitten J Am Chem Soc 107 3621 1985.] The acetate has m 114-115o from EtOAc/MeOH and, [] D 20 +13o (c 2, CHCl3). [Bruce & Ralls Org Synth Col Vol II 191 1943, Beilstein 6 IV 3577.]
Dihydrocholesterol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sri Neelima Laboratories | +91-7981733602 +91-9849736989 | Telangana, India | 205 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4217 | 58 | Inquiry |
| Siri Organics | 08985670323 | Hyderabad, India | 54 | 58 | Inquiry |
| Sri Neelima Laboratories | 08048372574Ext 232 | Hyderabad, India | 154 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| SRI Neelima Laboratories | +91 (984) 973-6989 | New Delhi, India | 40 | 0 | Inquiry |
| Supplier | Advantage |
|---|---|
| Sri Neelima Laboratories | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Reax Chemicals | 58 |
| Siri Organics | 58 |
| Sri Neelima Laboratories | 58 |
| CHEMSWORTH | 30 |
| SRI Neelima Laboratories | 0 |
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