Tomatidine hydrochloride
![Tomatidine hydrochloride Structure](CAS/GIF/6192-62-7.gif)
- CAS No.
- 6192-62-7
- Chemical Name:
- Tomatidine hydrochloride
- Synonyms
- TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL;3β-Hydroxy-5α-tomatidane hydrochloride
- CBNumber:
- CB6774105
- Molecular Formula:
- C27H46ClNO2
- Molecular Weight:
- 452.11
- MOL File:
- 6192-62-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/20 16:43:00
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
Tomatidine hydrochloride price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | T2909 | Tomatidine hydrochloride ≥85% | 6192-62-7 | 25MG | ₹7036.25 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T2909 | Tomatidine hydrochloride ≥85% | 6192-62-7 | 100MG | ₹20578.33 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 614350 | Tomatidine, HCl - CAS 6192-62-7 - Calbiochem A steroidal alkaloid that structurally resembles Cyclopamine, but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-ter | 6192-62-7 | 25MG | ₹9490 | 2022-06-14 | Buy |
Tomatidine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).
Biological Activity
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.
Mode of action
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
Tomatidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860 +86-18080483897 | China | 3777 | 58 | Inquiry |
Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | China | 952 | 58 | Inquiry |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 11616 | 58 | Inquiry |
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | China | 300 | 58 | Inquiry |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9624 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
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