Tomatidine hydrochloride

Tomatidine hydrochloride Structure
CAS No.
6192-62-7
Chemical Name:
Tomatidine hydrochloride
Synonyms
TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL;3β-Hydroxy-5α-tomatidane hydrochloride
CBNumber:
CB6774105
Molecular Formula:
C27H46ClNO2
Molecular Weight:
452.11
MOL File:
6192-62-7.mol
MSDS File:
SDS
Modify Date:
2023/9/20 16:43:00

Tomatidine hydrochloride Properties

Melting point 281-284°C (dec.)
storage temp. 2-8°C
solubility Methanol (Slightly)
form Off-white solid
color White to Off-White
BRN 3920740

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Safety Statements  22-24/25
WGK Germany  3
NFPA 704
0
2 0

Tomatidine hydrochloride price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T2909 Tomatidine hydrochloride ≥85% 6192-62-7 25MG ₹7036.25 2022-06-14 Buy
Sigma-Aldrich(India) T2909 Tomatidine hydrochloride ≥85% 6192-62-7 100MG ₹20578.33 2022-06-14 Buy
Sigma-Aldrich(India) 614350 Tomatidine, HCl - CAS 6192-62-7 - Calbiochem A steroidal alkaloid that structurally resembles Cyclopamine, but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-ter 6192-62-7 25MG ₹9490 2022-06-14 Buy
Product number Packaging Price Buy
T2909 25MG ₹7036.25 Buy
T2909 100MG ₹20578.33 Buy
614350 25MG ₹9490 Buy

Tomatidine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).

Biological Activity

Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.

Mode of action

Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.

Tomatidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 108)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +86-28-82633860 +86-18080483897 China 3777 58 Inquiry
Chengdu Greenpure Biopharma CO.,Ltd 18283602253; +8618283602253 China 952 58 Inquiry
Chengdu GLP biotechnology Co Ltd 028-87075086 13350802083 CHINA 1824 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Neostar United (Changzhou) Industrial Co., Ltd. +86-519-519-85557386 China 11616 58 Inquiry
Wuhan Nutra Biotechnology Co.,Ltd +8617786394783 China 300 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9624 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry

Tomatidine hydrochloride Spectrum

3BETA-HYDROXY-5ALPHA-TOMATIDANE HYDROCHLORIDE 5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE TOMATIDINE HCL TOMATIDINE HYDROCHLORIDE SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride TOMATIDINE HCL(RG) Tomatidine, Hydrochloride, >85% ToMatidin Hydrochloride, >85% 3β-Hydroxy-5α-tomatidane hydrochloride, 5α-Tomatidan-3β-ol hydrochloride (3β,5α,22β,25S)-Spirosolan-3-ol Hydrochloride (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride (1:1) 3β-Hydroxy-5α-tomatidane hydrochloride 5α-Tomatidan-3β-ol hydrochloride Tomatidine, HCl - CAS 6192-62-7 - Calbiochem Tomatidine Hydrochloride, > 5alpha-Tomatidan-3beta-ol HCl 6192-62-7 C27H46ClNO2 C27H45NO2HCl Lipid signaling Intermediates & Fine Chemicals Pharmaceuticals Steroids