ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Boric acid >4-PHENOXYPHENYLBORONIC ACID
4-PHENOXYPHENYLBORONIC ACID
- CAS No.
- 51067-38-0
- Chemical Name:
- 4-PHENOXYPHENYLBORONIC ACID
- Synonyms
- EOS-61617;AKOS BRN-0132;RARECHEM AH PB 0260;TIMTEC-BB SBB003409;Ibrutinib Impurity 36;4-PHENOXYPHENYLBORONI;4-Boronodiphenyl ether;4-PHENOXYPHENYLBORONIC;4-phenoxy-phenylboric acid;4-PHENOXYPHENYLBORONIC ACID
- CBNumber:
- CB9278200
- Molecular Formula:
- C12H11BO3
- Molecular Weight:
- 214.02
- MOL File:
- 51067-38-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 141-145 °C(lit.) |
|---|---|
| Boiling point | 377.0±44.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 8.76±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| InChI | InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H |
| InChIKey | KFXUHRXGLWUOJT-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O |
| CAS DataBase Reference | 51067-38-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
4-PHENOXYPHENYLBORONIC ACID price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 480142 | 4-Phenoxyphenylboronic acid ≥95.0% | 51067-38-0 | 5G | ₹6603.25 | 2022-06-14 | Buy |
| ALFA India | ALF-H52950-06 | 4-Phenoxybenzeneboronic acid, 98% | 51067-38-0 | 5g | ₹8260 | 2022-05-26 | Buy |
| ALFA India | ALF-H52950-03 | 4-Phenoxybenzeneboronic acid, 98% | 51067-38-0 | 1g | ₹1734 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1974 | 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) | 51067-38-0 | 5G | ₹6200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1974 | 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) | 51067-38-0 | 25G | ₹19800 | 2022-05-26 | Buy |
4-PHENOXYPHENYLBORONIC ACID Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder and chunk
Uses
4-Phenoxyphenylboronic acid can be used as a reactant:
- In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
- To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
- To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.
Synthesis
4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).
4-PHENOXYPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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Global( 384)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Integrum Life Sciences Private Limited | +91-9502471357 +91-9502471357 | Telangana, India | 13 | 58 | Inquiry |
| Denisco Chemicals Pvt Ltd | +91-9989050751 | Telangana, India | 249 | 58 | Inquiry |
| Aktinos Pharma Pvt Ltd | +91-4048541177 +91-4048541177 | Telangana, India | 42 | 58 | Inquiry |
| Denisco Chemicals Pvt., Ltd. | 91-40-23552990 | Hyderabad, India | 174 | 58 | Inquiry |
| Hrishabh Life Sciences | 91-22-62215755 | Maharashtra, India | 159 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 91-79-26462688 | Gujarat, India | 987 | 58 | Inquiry |
| Anji Biosciences | +91 40 40154989 | Hyderabad, India | 201 | 58 | Inquiry |
| Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group) | 91-22-42361111 | Maharashtra, India | 147 | 58 | Inquiry |
| Anax Laboratories | +91 (40) 6464-2010 | New Delhi, India | 177 | 0 | Inquiry |
51067-38-0(4-PHENOXYPHENYLBORONIC ACID)Related Search:
4-PHENOXYBENZOIC ACID
(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID
3,4,5-Trifluorophenylboronic acid
4-Chloro-2-fluoro-3-methoxyphenylboronic acid
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4-PHENOXYBENZENEBORONIC ACID
4-PHENOXYPHENYLBORONIC ACID
AKOS BRN-0132
RARECHEM AH PB 0260
(P-PHENOXYPHENYL)BORONIC ACID
TIMTEC-BB SBB003409
4-Phenoxybenzeneboronic acid 98%
4-Phenoxyphenylboronic acid,97%
4-Phenoxyphenylboronic acid ,98%
4-Phenoxyphenylboronic Acid (contains varying aMounts of Anhydride)
4-Phenoxyphenylboronic acid, 97% 1GR
4-Boronodiphenyl ether
4-Phenoxyphenylboronic acid >=95.0%
EOS-61617
4-Phenoxyphenylboronic acid Ibrutinib
Ibrutinib Impurity 36
4-Phenoxyphenylboronic acid, 98%, for synthesis
Boronic acid, B-(4-phenoxyphenyl)-
4-PHENOXYPHENYLBORONI
4-phenoxy-phenylboric acid
4-PHENOXYPHENYLBORONIC
51067-38-0
C12H11BO3
Aryl
Boronic Acids
Boronic Acids and Derivatives
Organometallic Reagents
blocks
BoronicAcids
Heterocyclic Compounds
Aryl
Organoborons
Boronic Acids
Boronic Acids and Derivatives
Boronic Acids