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1-Methyl-4-pyrazole boronic acid pinacol ester

CAS No.: 761446-44-0

Chemical Name:: 1-Methyl-4-pyrazole boronic acid pinacol ester

Synonyms: 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-4-(4;Angelica oil 8015-64-3;e-4-boronic acid pinacoL;1-Methylpyrazole-4-boroni...;1-Methyl-4-(4,4,5,5-Tetramethy

CBNumber:: CB0414153

Molecular Formula:: C10H17BN2O2

Molecular Weight:: 208.07

MOL File:: 761446-44-0.mol

Modify Date:: 2024/1/3 13:33:01

Request For Quotation

1-Methyl-4-pyrazole boronic acid pinacol ester Properties

Melting point	59-64 °C(lit.)
Boiling point	308.3±15.0 °C(Predicted)
Density	1.05±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (slightly), Methanol (Slightly)
pka	2.09±0.10(Predicted)
form	Crystals
color	Off-white to yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChIKey	UCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILES	N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS DataBase Reference	761446-44-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Xn,F,Xi

Risk Statements

22-36/37/38

Safety Statements

26-36-37/39

WGK Germany

Hazard Note

Irritant/Flammable

TSCA

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	1
2		0

1-Methyl-4-pyrazole boronic acid pinacol ester price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	595314	1-Methylpyrazole-4-boronic acid pinacol ester 95%	761446-44-0	1G	₹5585.7	2022-06-14	Buy
Sigma-Aldrich(India)	595314	1-Methylpyrazole-4-boronic acid pinacol ester 95%	761446-44-0	5G	₹21617.53	2022-06-14	Buy
Sigma-Aldrich(India)	595314	1-Methylpyrazole-4-boronic acid pinacol ester 95%	761446-44-0	25G	₹61561.78	2022-06-14	Buy
TCI Chemicals (India)	M2339	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole min. 98.0 %	761446-44-0	1G	₹4800	2022-05-26	Buy
TCI Chemicals (India)	M2339	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole min. 98.0 %	761446-44-0	5G	₹10800	2022-05-26	Buy

Product number	Packaging	Price	Buy
595314	1G	₹5585.7	Buy
595314	5G	₹21617.53	Buy
595314	25G	₹61561.78	Buy
M2339	1G	₹4800	Buy
M2339	5G	₹10800	Buy

1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powde

Uses

1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

Synthesis

To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.

1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Trimethyl borate Pinacol Potassium hydroxide 4-Bromopyrazole Tetrahydrofuran

5A molecular sieve Methyl bromide Iodomethane n-Butyllithium 4-Iodo-1-methyl-1H-pyrazole

4-Bromo-1-methylpyrazole 4-Chloro-1-methylpyrazole 1-Methyl-1H-pyrazole-4-boronic acid 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Pyrazoleboronic acid pinacol ester

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Preparation Products

1-Methyl-1H-pyrazole-5-boronic acid pinacol ester 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)Quinoxaline 1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-4-pyrazole boronic acid pinacol ester Suppliers

Global( 423)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
GLR Innovations	+91 9891111994	New Delhi, India	4542	58	Inquiry
Sam Research Labs	+91 9873930190	Hyderabad, India	219	58	Inquiry
ANWITA APIS	+919000311012	Hyderabad, India	198	58	Inquiry
SPD CHEMICALS	+91-7075800742 +91-7075800742	Hyderabad, India	214	58	Inquiry
JAY CHEMICALS	+91-9819633090 +91-9819633090	Maharashtra, India	85	58	Inquiry
VGS SYNTHESIS PRIVATE LIMITED	+91-9866975588 +91-9866975588	Hyderabad, India	1818	58	Inquiry
ALTAIR ALCHEMY Laboratories	91--9014276848	Hyderabad, India	324	58	Inquiry
Clininvent Research Pvt., Ltd. (a part of TCG Lifesciences Pvt., Ltd.)		Hyderabad, India	7	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Gagri Global IT Services Pvt. Ltd.	+91-40-27170174,	Telangana, India	1321	58	Inquiry

Supplier	Advantage
GLR Innovations	58
Sam Research Labs	58
ANWITA APIS	58
SPD CHEMICALS	58
JAY CHEMICALS	58
VGS SYNTHESIS PRIVATE LIMITED	58
ALTAIR ALCHEMY Laboratories	58
Clininvent Research Pvt., Ltd. (a part of TCG Lifesciences Pvt., Ltd.)	58
CLEARSYNTH LABS LTD.	58
Gagri Global IT Services Pvt. Ltd.	58

1-Methyl-4-pyrazole boronic acid pinacol ester Spectrum

1-Methyl-4-pyrazole boronic acid pinacol ester(761446-44-0)¹HNMR 1-Methyl-4-pyrazole boronic acid pinacol ester(761446-44-0)FT-IR

761446-44-0(1-Methyl-4-pyrazole boronic acid pinacol ester)Related Search:

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1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2- 1-METHYL- 4-PYRAZOLEBORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TERAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1-methyl-4-(4，4，5，5-tetramethyl-1，3，2-dioxaborolan-2-yl)-1H- 1-Methyl-4-pyrazoleboronic acid pinacol ester, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5-trimethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+% 2-(1-Methylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylpyrazole 1-Methyl-4-(4,4,5,5-Tetramethy 1-Methyl-4-Pyridineboronic acid pinacol ester 1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1-Methyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1-Methylpyrazole-4-boronic acid pinacol ester 95% 1-Methylpyrazole-4-boronic acid pinacol ester 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-1H-pyrazole-4-boronic acid pinacol -Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan 3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1-Methyl-1H-pyrazol-4-ylboronate 1-METHYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-1H-PYRAZOLE 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole1-Methylpyrazole-4-boronic acid pinacol ester 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ,95% 1-Methylpyrazole-4-boronic acid pinacol ester ,98% 1-Methylpyrazole-4-boroni... 1-Methyl-4-(4 1-Methy-4-(4,4,5,5,-tertamethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-Methylpyrazole-4-boronic acid pinacol ester (Related Reference) 1-MethylPyrazole-4-Boronic acid Pinacolate 2-(1-Methyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1-Methyl-1H-pyrazole-4-boronic acid, pinacol ester 99% 1-methyl-4-(4-tetramethyl-1-dioxaborolan-2-yl)-1H- 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole> e-4-boronic acid pinacoL (1-METHYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole 1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE 1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER 1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER 1- methylpyrazole -4- boracic acid methyl alcohol ester Angelica oil 8015-64-3 Tranexamic Acid Impurity 27-13C2 N-Methylpyrazole-4-boronicacidpinacolester 761446-44-0 761446-18-6 76146-44-0 C10H17BN2O2 C10H19BN2O3 Boronate Esters Boronic Acids and Derivatives Chemical Synthesis Heteroaryl Boronate Esters Organometallic Reagents Heterocyclic Building Blocks Organoborons Pyrazole Boronic acid