1-Methyl-4-pyrazole boronic acid pinacol ester
![1-Methyl-4-pyrazole boronic acid pinacol ester Structure](CAS/GIF/761446-44-0.gif)
- CAS No.
- 761446-44-0
- Chemical Name:
- 1-Methyl-4-pyrazole boronic acid pinacol ester
- Synonyms
- 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-4-(4;Angelica oil 8015-64-3;e-4-boronic acid pinacoL;1-Methylpyrazole-4-boroni...;1-Methyl-4-(4,4,5,5-Tetramethy
- CBNumber:
- CB0414153
- Molecular Formula:
- C10H17BN2O2
- Molecular Weight:
- 208.07
- MOL File:
- 761446-44-0.mol
- Modify Date:
- 2024/1/3 13:33:01
Melting point | 59-64 °C(lit.) |
---|---|
Boiling point | 308.3±15.0 °C(Predicted) |
Density | 1.05±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Chloroform (slightly), Methanol (Slightly) |
pka | 2.09±0.10(Predicted) |
form | Crystals |
color | Off-white to yellow |
Water Solubility | Slightly soluble in water. |
InChI | InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3 |
InChIKey | UCNGGGYMLHAMJG-UHFFFAOYSA-N |
SMILES | N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1 |
CAS DataBase Reference | 761446-44-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
Hazard Codes | Xn,F,Xi | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant/Flammable | |||||||||
TSCA | No | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29349990 | |||||||||
NFPA 704 |
|
1-Methyl-4-pyrazole boronic acid pinacol ester price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 595314 | 1-Methylpyrazole-4-boronic acid pinacol ester 95% | 761446-44-0 | 1G | ₹5585.7 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 595314 | 1-Methylpyrazole-4-boronic acid pinacol ester 95% | 761446-44-0 | 5G | ₹21617.53 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 595314 | 1-Methylpyrazole-4-boronic acid pinacol ester 95% | 761446-44-0 | 25G | ₹61561.78 | 2022-06-14 | Buy |
TCI Chemicals (India) | M2339 | 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole min. 98.0 % | 761446-44-0 | 1G | ₹4800 | 2022-05-26 | Buy |
TCI Chemicals (India) | M2339 | 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole min. 98.0 % | 761446-44-0 | 5G | ₹10800 | 2022-05-26 | Buy |
1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powde
Uses
1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
Synthesis
To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.
1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
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