ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >Transferase Inhibitors >Tolcapone
Tolcapone
- CAS No.
- 134308-13-7
- Chemical Name:
- Tolcapone
- Synonyms
- Tasmar;TOLCAPONE;TALCAPONE;ro40-7592;TOLOCAPONE;Tolcapone (200 mg);TolcaponeTolcapone;Tolcapone USP/EP/BP;Tolcapone (1670207);(3,4-Dihydroxy-5-nitrophenyl)
- CBNumber:
- CB9302569
- Molecular Formula:
- C14H11NO5
- Molecular Weight:
- 273.24
- MOL File:
- 134308-13-7.mol
- Modify Date:
- 2023/9/20 16:43:00
| Melting point | 126-1280C |
|---|---|
| Boiling point | 485.6±45.0 °C(Predicted) |
| Density | 1.419±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥15mg/mL |
| pka | 4.78±0.38(Predicted) |
| form | powder |
| color | yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| CAS DataBase Reference | 134308-13-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H400 |
| Precautionary statements | P273 |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| RTECS | PC4952500 |
| HS Code | 2914710000 |
| Toxicity | mouse,LD50,oral,1600mg/kg (1600mg/kg),BEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl, |
Tolcapone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0150 | Tolcapone ≥98% (HPLC) | 134308-13-7 | 10MG | ₹9212.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0150 | Tolcapone ≥98% (HPLC) | 134308-13-7 | 50MG | ₹38082.35 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3856 | Tolcapone | 134308-13-7 | 50MG | ₹3900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3856 | Tolcapone | 134308-13-7 | 200MG | ₹8900 | 2022-05-26 | Buy |
Tolcapone Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
Tolcapone may be used in COMT-mediated cell signaling studies.
Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.
Preparation
preparation by demethylation of 4-hydroxy-3-methoxy-4′-methyl-5-nitrobenzophenone with hydrobromic acid in refluxing aque-ous acetic acid.
General Description
Tolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pKa＝4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (＞98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney. The majormetabolite of tolcapone is an inactive glucuronide conjugate.COMT inhibitors increase chronotropic and arrhythmogeniceffects of epinephrine.Tolcapone is indicated as an adjunctto levodopa/carbidopa for the management of signs andsymptoms of PD.
Tolcapone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 226)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SNA HEALTHCARE PVT LTD | +91-8652842416 +91-8652842416 | Mumbai, India | 88 | 58 | Inquiry |
| Cohance Lifesciences (Previously RA Chem Pharma Ltd) | +91-4044758595 +91-4044758595 | Telangana, India | 47 | 58 | Inquiry |
| PIRAMAL PHARMA LTD | +91-22-3802 3000 | New Delhi, India | 28 | 58 | Inquiry |
| GLOCHEM INDUSTRIES LTD | +91 40 3921 9900 | New Delhi, India | 3 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| RA CHEM PHARMA LTD | +91-40-4475 8595 | New Delhi, India | 37 | 58 | Inquiry |
| CLEANCHEM LABORATORIES LLP | +91 98921 69560 | New Delhi, India | 326 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
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TOLOCAPONE
3,4-DIHYDROXYL-5-NITROBENZENYL,4-METHYLBENZENYL KETONE, TALCAPONE
Tolcapone (200 mg)
Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-Methylphenyl)-
(3,4-Dihydroxy-5-nitrophenyl)(p-tolyl)methanone
3,4-DIHYDROXYL-5-NITROBENZYL,4'-METHYLBENZENYL KETONE
(3,4-Dihydroxy-5-nitrophenyl)
TALCAPONE
TOLCAPONE
(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-methanon
(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
3,4-dihydroxy-4’-methyl-5-nitrobenzophenone
ro40-7592
TolcaponeTolcapone
Tasmar
Tolcapone USP/EP/BP
TolcaponeQ: What is
Tolcapone Q: What is the CAS Number of
Tolcapone Q: What is the storage condition of
Tolcapone Q: What are the applications of
Tolcapone
Tolcapone (1670207)
3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
134308-13-7
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134308-13-7