Tolcapone manufacturers and suppliers in india

Tolcapone

Properties

Melting point:: 126-1280C

Boiling point:: 485.6±45.0 °C(Predicted)

Density: 1.419±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: ≥15mg/mL

pka: 4.78±0.38(Predicted)

form: powder

color: yellow

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS09

Signal word: Warning

Hazard statements: H400

Precautionary statements: P273

Hazard Codes: N

Risk Statements: 50

Safety Statements: 61

RIDADR: UN 3077 9 / PGIII

RTECS: PC4952500

HS Code: 2914710000

Toxicity: mouse,LD50,oral,1600mg/kg (1600mg/kg),BEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl,

Use

Tolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pKa＝4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (＞98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney. The majormetabolite of tolcapone is an inactive glucuronide conjugate.COMT inhibitors increase chronotropic and arrhythmogeniceffects of epinephrine.Tolcapone is indicated as an adjunctto levodopa/carbidopa for the management of signs andsymptoms of PD.