Tolcapone
Tolcapone
- CAS:
- 134308-13-7
- MF:
- C14H11NO5
- MW:
- 273.24
Suppliers by country/region
Company Type
Properties
- Melting point:
- 126-1280C
- Boiling point:
- 485.6±45.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥15mg/mL
- pka
- 4.78±0.38(Predicted)
- form
- powder
- color
- yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety Information
- Symbol(GHS)
GHS09
- Signal word
- Warning
- Hazard statements
- H400
- Precautionary statements
- P273
- Hazard Codes
- N
- Risk Statements
- 50
- Safety Statements
- 61
- RIDADR
- UN 3077 9 / PGIII
- RTECS
- PC4952500
- HS Code
- 2914710000
- Toxicity
- mouse,LD50,oral,1600mg/kg (1600mg/kg),BEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl,
Use
Tolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pKa=4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (>98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney. The majormetabolite of tolcapone is an inactive glucuronide conjugate.COMT inhibitors increase chronotropic and arrhythmogeniceffects of epinephrine.Tolcapone is indicated as an adjunctto levodopa/carbidopa for the management of signs andsymptoms of PD.
11 India supplier list of "Tolcapone"
![](/images/pro-3.jpg)
- Product Name:Tolcapone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Tolcapone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Tolcapone
- Products Intro:Brand:sigma aldrich | Product Number:SML0150 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Tolcapone
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Tolcapone
- Products Intro:Brand:synzeal | Product Number:128265490
- Company Type: Trader
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Tolcapone
- Company Type: Reagent
- Country/Region: INDIA