GSK 2033
- CAS No.
- 1221277-90-2
- Chemical Name:
- GSK 2033
- Synonyms
- GSK 2033;LXR antagonist 2033;GSK2033 >=98% (HPLC);Liver X receptor,Inhibitor,GSK 2033,inhibit,LXR,GSK2033,GSK-2033;2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide;Benzenesulfonamide, 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-
- CBNumber:
- CB93146298
- Molecular Formula:
- C29H28F3NO5S2
- Molecular Weight:
- 591.66
- MOL File:
- 1221277-90-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
GSK 2033 price More Price(2)
GSK 2033 Chemical Properties,Uses,Production
Uses
GSK 2033 is a potent LXR antagonist.
Biochem/physiol Actions
GSK2033 is an antagonist of the nuclear receptor liver-X-receptor (LXR) with pIC50 values of 7.0 for LXRα and 7.4 for LXRβ. Treatment of murine CD41 T cells with GSK2033 enhanced cellular proliferation and Th1/Th2/Th17 differentiation. In another study, the conjugated linoleic acid (CLA)-induced expression of efflux protein ATP-binding-cassette transporter A1 (ABCA1) was completely abolished by preincubation with GSK2033, showing that CLA mediated regulation of ABCA-1 expression is LXR dependent.
GSK 2033 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK 2033 Suppliers
Global( 50)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | China | 2974 | 58 | Inquiry |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | China | 3465 | 58 | Inquiry |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | China | 3770 | 55 | Inquiry |
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GSK 2033
LXR antagonist 2033
2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
Benzenesulfonamide, 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-
GSK2033 >=98% (HPLC)
Liver X receptor,Inhibitor,GSK 2033,inhibit,LXR,GSK2033,GSK-2033
1221277-90-2
C29H28F3NO5S2