Cellulose acetate phthalate
- CAS No.
- 9004-38-0
- Chemical Name:
- Cellulose acetate phthalate
- Synonyms
- cap-wako;CELLACEFATE;cellacetate;CELLACEFATE,NF;Fiber acetate ester;acetylphthalylcellulose;celluloseacetophthalate;celluloseacetylphthalate;ELLULOSE ACETATE PHTHALATE;CELLULOSE ACETATE PHTHALATE
- CBNumber:
- CB9396579
- Molecular Formula:
- C116H116O64
- Molecular Weight:
- 2534.12
- MOL File:
- Mol file
- Modify Date:
- 2024/5/10 19:09:13
| solubility | Practically insoluble in water, freely soluble in acetone, soluble in diethylene glycol, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides |
|---|---|
| EPA Substance Registry System | Cellulose, acetate hydrogen 1,2-benzenedicarboxylate (9004-38-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H252-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P235+P410-P280-P407-P413-P420-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| RTECS | FJ5692000 |
| HS Code | 39129010 |
Cellulose acetate phthalate price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 22192 | Cellulose acetate phthalate | 9004-38-0 | 100G | ₹6711.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 22192 | Cellulose acetate phthalate | 9004-38-0 | 100G | ₹6711.5 | 2022-06-14 | Buy |
| Sigma-Aldrich | 22192 | Cellulose acetate phthalate | 9004-38-0 | 500G | ₹27636.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 22192 | Cellulose acetate phthalate | 9004-38-0 | 500G | ₹27636.23 | 2022-06-14 | Buy |
| ottokemi | C 1766 | Cellulose acetate phthalate | 9004-38-0 | 100gm | ₹675 | 2022-05-26 | Buy |
Cellulose acetate phthalate Chemical Properties,Uses,Production
Chemical Properties
Cellulose acetate phthalate is a hygroscopic, white to off-white, freeflowing powder, granule, or flake. It is tasteless and odorless, or might have a slight odor of acetic acid.
Uses
Enteric coating in pharmaceutical products.
Production Methods
Cellulose acetate phthalate is produced by reacting the partial acetate ester of cellulose with phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid.
Pharmaceutical Applications
Cellulose acetate phthalate (CAP) is used as an enteric film coating
material, or as a matrix binder for tablets and capsules. Such
coatings resist prolonged contact with the strongly acidic gastric
fluid, but dissolve in the mildly acidic or neutral intestinal
environment.
Cellulose acetate phthalate is commonly applied to solid-dosage
forms either by coating from organic or aqueous solvent systems, or
by direct compression. Concentrations generally used are 0.5–9.0%
of the core weight. The addition of plasticizers improves the water
resistance of this coating material, and formulations using such
plasticizers are more effective than when cellulose acetate phthalate
is used alone.
Cellulose acetate phthalate is compatible with many plasticizers,
including acetylated monoglyceride; butyl phthalybutyl glycolate;
dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl
phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin
citrate; and tripropionin. It is also used in combination with
other coating agents such as ethyl cellulose, in drug controlledrelease
preparations.
Therapeutically, cellulose acetate phthalate has recently been
reported to exhibit experimental microbicidal activity against
sexually transmitted disease pathogens, such as the HIV-1 retrovirus.
Safety Profile
An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety
Cellulose acetate phthalate is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material, free of adverse effects. Results of long-term feeding in rats and dogs have indicated a low oral toxicity. Rats survived daily feedings of up to 30% in the diet for up to 1 year without showing a depression in growth. Dogs fed 16 g daily in the diet for 1 year remained normal.
storage
Slow hydrolysis of cellulose acetate phthalate will occur under prolonged adverse conditions such as high temperatures and high humidity, with a resultant increase in free acid content, viscosity, and odor of acetic acid. However, cellulose acetate phthalate is stable if stored in a well-closed container in a cool, dry place.
Incompatibilities
Cellulose acetate phthalate is incompatible with ferrous sulfate, ferric chloride, silver nitrate, sodium citrate, aluminum sulfate, calcium chloride, mercuric chloride, barium nitrate, basic lead acetate, and strong oxidizing agents such as strong alkalis and acids.
Regulatory Status
Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Cellulose acetate phthalate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Anubhav Business Corporation | +91-2228014519 +91-2228014999 | Maharashtra, India | 119 | 58 | Inquiry |
| Deepak Cellulose Pvt Ltd | +91-8200186602 +91-8056298777 | Gujarat, India | 3 | 58 | Inquiry |
| G M Chemie Pvt Ltd | +91-9820793601 +91-9820793601 | Maharashtra, India | 1 | 58 | Inquiry |
| Nutracare International | +91-2228065292 +91-9820315046 | Maharashtra, India | 36 | 58 | Inquiry |
| Panchamrut Chemicals | 08048965188 | Mumbai, India | 86 | 58 | Inquiry |
| Hemax Pharmacoat | 08068441031Ext 812 | Mumbai, India | 4 | 58 | Inquiry |
| G. M. Chemie Private Limited | 08068441025Ext 898 | Mumbai, India | 3 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| PERFECT CHEMICAL | 58 |
| JSK Chemicals | 58 |
| Medi Pharma Drug House | 58 |
| Anubhav Business Corporation | 58 |
| Deepak Cellulose Pvt Ltd | 58 |
| G M Chemie Pvt Ltd | 58 |
| Nutracare International | 58 |
| Panchamrut Chemicals | 58 |
| Hemax Pharmacoat | 58 |
| G. M. Chemie Private Limited | 58 |
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