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CARBENICILLIN INDANYL SODIUM

CARBENICILLIN INDANYL SODIUM Structure
CAS No.
26605-69-6
Chemical Name:
CARBENICILLIN INDANYL SODIUM
Synonyms
i-cbpc;C12712;GU-Pen;cp15464-2;geocillin;carindapen;carindacillin;carindacillinsodium;carbenicillinindanyl;carbenicillinindanylsodium
CBNumber:
CB9501393
Molecular Formula:
C26H26N2O6S.Na
Molecular Weight:
0
MOL File:
26605-69-6.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:22
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CARBENICILLIN INDANYL SODIUM Properties

Melting point 207-213°
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Water (Slightly, Heated, Sonicated)
form Solid
color White to Off-White
Stability Hygroscopic, Temperature Sensitive

SAFETY

Risk and Safety Statements

HS Code  2941106000

CARBENICILLIN INDANYL SODIUM Chemical Properties,Uses,Production

Description

Carbenicillin indanyl was synthesized by Pfizer in 1972 as an orally active carbenicillin. It shows strong activity against a variety of bacteria in vitro, and, when administered orally, it behaves as carbenicillin after being hydrolyzed by intestinal esterase.

Uses

Carbenicillin indanyl sodium has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.

Clinical Use

Efforts to obtain orally active forms of carbenicillin led to theeventual release of the 5-indanyl ester carbenicillin indanyl,6-[2-phenyl-2-(5-indanyloxycarbonyl)acetamido]penicillanicacid (Geocillin), in 1972. Approximately 40% of theusual oral dose of indanyl carbenicillin is absorbed. After absorption,the ester is hydrolyzed rapidly by plasma and tissueesterases to yield carbenicillin. Thus, although the highlylipophilic and highly protein-bound ester has in vitro activitycomparable with that of carbenicillin, its activity in vivo isdue to carbenicillin. Indanyl carbenicillin thus provides anorally active alternative for the treatment of carbenicillinsensitivesystemic and urinary tract infections caused byPseudomonas spp., indole-positive Proteus spp., and selectedspecies of Gram-negative bacilli.
Clinical trials with indanyl carbenicillin revealed a relativelyhigh frequency of GI symptoms (nausea, occasionalvomiting, and diarrhea). It seems doubtful that the highdoses required for the treatment of serious systemic infectionscould be tolerated by most patients. Indanyl carbenicillinoccurs as the sodium salt, an off-white, bitter powderthat is freely soluble in water. It is stable in acid. It should beprotected from moisture to prevent hydrolysis of the ester.

CARBENICILLIN INDANYL SODIUM Preparation Products And Raw materials

Raw materials

Phosphorus pentachloride Triethylamine Phenylmalonic acid 6-Aminopenicillanic acid

Preparation Products

CARBENICILLIN INDANYL SODIUM Suppliers

Global( 21)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Alfa Chemistry +1-5166625404 United States 21317 58 Inquiry
guoyungurui 18162595016 China 10012 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28118 58 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Shaanxi Dideu Medichem Co. Ltd 58
Dideu Industries Group Limited 58
AFINE CHEMICALS LIMITED 58
Alfa Chemistry 58
guoyungurui 58
TargetMol Chemicals Inc. 58
United States Biological 80

26605-69-6(CARBENICILLIN INDANYL SODIUM)Related Search:

Ticarcillin 5-INDANOL Penicillin G sodium salt CARINDACILLIN CARBENICILLIN PHENYL SODIUM
M-CRESYL PHENYLACETATE CARBENICILLIN INDANYL SODIUM sodium [2S-(2alpha,5alpha,6beta)]-6-[(1,3-dioxo-3-phenoxy-2-phenylpropyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate CARBENICILLIN AKOS BC-1945
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Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenyl-, 1-(5-indanyl) ester, monosodium salt (8CI) Monosodium indanyl carbenicillin Sodium 5-indanylcarbenicillin Sodium indanylcarbenicillin CARBENICILLIN INDANYL SODIUM (300 MG) 6-yl)-2-phenyl-,1-(5-indanyl)ester,monosodiumsalt carbenicillinindanyl carbenicillinindanylsodium carindacillinsodium carindapen cp15464-2 geocillin i-cbpc indanylcarbenicillinsodiumsalt n-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-malonamicaci C12712 Sodium Indanylcarbinicillin carindacillin 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]- 5-Indanol, 6-ester with 6-(2-carboxy-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt (8CI) 5-Indanol, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenylmalonamate monosodium salt (8CI) GU-Pen CARBENICILLIN INDANYL SODIUM USP/EP/BP Carbenicillin Indanyl Sodium (1093500) QFWPXOXWAUAYAB-XZVIDJSISA-M Methylphenidate Hydrochloride Impurity 4 (Methylphenidate Hydrochloride EP Impurity D) 26605-69-6 C26H26N2O6SNa C26H25N2NaO6S