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Ipratropium bromide

Ipratropium bromide Structure
CAS No.
22254-24-6
Chemical Name:
Ipratropium bromide
Synonyms
Ipratropium;Ipratropium Bromide anhydrous;atrovent;IPRATROPIUM BROMIDE EP;[(1r,5s)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide;atem;pate;PATE1;itrop;YB-API
CBNumber:
CB9715938
Molecular Formula:
C20H30BrNO3
Molecular Weight:
412.37
MOL File:
22254-24-6.mol
MSDS File:
SDS
Modify Date:
2024/4/24 17:21:45
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Ipratropium bromide Properties

Melting point 230-232°C
RTECS YM3700000
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 10 mg/mL
form powder
color white
Water Solubility Freely soluble
Stability Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 22254-24-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H319-H332
Precautionary statements  P261-P280i-P301+P312a-P304+P340-P305+P351+P338-P501a
Hazard Codes  Xn
Risk Statements  20/22-36
Safety Statements  26
WGK Germany  3
Toxicity LD50 in male, female mice (mg/kg): 1001, 1083 orally; 12.29, 14.97 i.v.; 300, 340 s.c.; LD50 in male, female rats (mg/kg): 1663, 1779 orally; 15.89, 15.70 i.v. (Sarafana)
NFPA 704
0
3 0

Ipratropium bromide Chemical Properties,Uses,Production

Chemical Properties

White Powder

Uses

Ipratropium Bromide is a nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.

Definition

ChEBI: The anhydrous form of the bromide salt of ipratropium. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstru tive pulmonary disease and acute asthma.

General Description

Ipratropium bromide, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide (Atrovent), is a quaternaryammonium derivative of atropine. It is freely soluble inwater and ethanol but insoluble in chloroform and ether. Thesalt is stable in neutral and acidic solutions but rapidly hydrolyzedin alkaline solutions.

Biological Activity

Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.

Clinical Use

Ipratropium bromide is used in inhalation therapy toproduce dilation of bronchial smooth muscle for acute asthmaticattacks. The drug produces bronchodilation by competitiveinhibition of cholinergic receptors bound to smooth muscle of the bronchioles. Ipratropium may also act on thesurface of mast cells to inhibit ACh-enhanced release ofchemical mediators. The drug has a slow onset of action,within 5 to 15 minutes after being administered by inhalation,and should not be used alone for acute asthmatic attacks.The peak therapeutic effect from one dose is observedbetween 1 and 2 hours. The effects of the drug last for about6 hours. It has a half-life of 3.5 hours.

Ipratropium bromide Preparation Products And Raw materials

Raw materials

Methyl bromide endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

Preparation Products

Ipratropium bromide Suppliers

Global( 250)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
AARTI INDUSTRIES LIMITED 912267976666 New Delhi, India 172 58 Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
Cipla Ltd +912224826000 Maharashtra, India 133 58 Inquiry
Aarti Industries Limited (AIL) +91-84596144931 +91-9920899935 Maharashtra, India 235 58 Inquiry
MELODY HEALTHCARE PVT LTD +undefined2228780912 Maharashtra, India 20 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Humble Healthcare Limited +91-9720093000 +91-8006400378 Uttar Pradesh, India 141 58 Inquiry
Navone Specialties (OPC) Pvt Ltd +91-9323789882 +91-9323789882 Maharashtra, India 144 58 Inquiry
AARTI INDUSTRIES LTD +91 22 6797 6666 New Delhi, India 32 58 Inquiry
Neuland Laboratories Limited +91 (40) 2341-2934 New Delhi, India 24 50 Inquiry
Supplier Advantage
AARTI INDUSTRIES LIMITED 58
J S LABS 58
Cipla Ltd 58
Aarti Industries Limited (AIL) 58
MELODY HEALTHCARE PVT LTD 58
Ralington Pharma 58
Humble Healthcare Limited 58
Navone Specialties (OPC) Pvt Ltd 58
AARTI INDUSTRIES LTD 58
Neuland Laboratories Limited 50

Ipratropium bromide Spectrum

Ipratropium bromide(22254-24-6)1HNMR

22254-24-6(Ipratropium bromide)Related Search:

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N-Isopropylatropinium bromide Sch 100 IPTRATROPIUM BROMIDE Ipratropium bromide (endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octanebromide Ipratropium bromide monohydrate,Atropine isopropyl bromide (3-endo,8-syn)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane, bromide (1:1) ANTI-PATE1 (C-TERM) antibody produced in rabbit PATE1 Prostate and testis expressed protein 1 (1s,3s,5r)-3-tropyloxy-8-isopropyltropaniumbromide (8r)-3-alpha-hydroxy-8-isopropyl-1-alpha-h,5-alpha-h-tropiumbromide-(+-)-tro 1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-isopropyl-,bromide,(+-)-trop 3-alpha-hydroxy-8-isopropyl-1-alpha-h,5-alpha-h-tropaniumbromide(+-)-tropat 8-isopropylnoratropinemethobromide atem ipratropiumbromid itrop n-isopropylnoratropiniumbromomethylate pate sch1000 IPRATROPIUM BROMIDE HYDRATE (ENDO,SYN)-(+/-)-3-(3-HYDROXY-1-OXO-2-PHENYLPROPOXY)-8-METHYL-8-(1-METHYLETHYL)-8-AZONIABICYCLO[3.2.1]OCTANE BROMIDE ATROPINE ISOPROPYLBROMIDE Atropine Isopropyl Bromid IPRATROPIUMBROMIDE,BP,EP 1αH,5αH-Tropanium, 3α-hydroxy-8-isopropyl-, bromide, (+-)-tropate (8CI) 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (3-endo,8-syn)- 3-(3-HYDROXY-1-OXO-2-PHENYLPROPOXY)-8-METHYL-8-(1-METHYLETHYL)-8-AZONIABICYCLO[3.2.1]-OCTANE BROMIDE (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropyl)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane Bromode Monohydrate 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, (endo,syn)-, bromide 8-Isopropylatropinium bromide 3-alpha-Hydroxy-8-isopropyl-1-alpha-H,5-alpha-H-tropanium bromide (±)-tropate 2-Methyl-2-[(piperidinomethyl)thio]propionic acid 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)- 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)-(+-)- 8-Isopropylatropinium bromide (6CI, 7CI) Atrovent forte Ipratropium D3 3-hydroxy-2-phenylpropanoic acid [(1S,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester bromide hydrate Ipratropium bromide USP/EP/BP Ipratropium bromide salt Ipratropium Bromide (Sch 1000) Ipratropium BromideQ: What is Ipratropium Bromide Q: What is the CAS Number of Ipratropium Bromide Q: What is the storage condition of Ipratropium Bromide Q: What are the applications of Ipratropium Bromide Ipratropium Bromide anhydrous atrovent Ipratropium IPRATROPIUM BROMIDE EP [(1r,5s)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide 2H6]-Ipratropium bromide salt Atrovent Hfa YB-API rel-(1R,3r,5S,8s)-3-((3-Hydroxy-2-phenylpropanoyl)oxy)-8-isopropyl-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide 22254-24-6 2254-24-6 47526-32-7 C20H30NO3BrH2O C20H30NO3Br