Ipratropium bromide
![Ipratropium bromide Structure](CAS/GIF/22254-24-6.gif)
- CAS No.
- 22254-24-6
- Chemical Name:
- Ipratropium bromide
- Synonyms
- Ipratropium;Ipratropium Bromide anhydrous;atrovent;IPRATROPIUM BROMIDE EP;[(1r,5s)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide;atem;pate;PATE1;itrop;YB-API
- CBNumber:
- CB9715938
- Molecular Formula:
- C20H30BrNO3
- Molecular Weight:
- 412.37
- MOL File:
- 22254-24-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/24 17:21:45
Melting point | 230-232°C |
---|---|
RTECS | YM3700000 |
storage temp. | Inert atmosphere,Room Temperature |
solubility | H2O: 10 mg/mL |
form | powder |
color | white |
Water Solubility | Freely soluble |
Stability | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 22254-24-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H319-H332 | |||||||||
Precautionary statements | P261-P280i-P301+P312a-P304+P340-P305+P351+P338-P501a | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 20/22-36 | |||||||||
Safety Statements | 26 | |||||||||
WGK Germany | 3 | |||||||||
Toxicity | LD50 in male, female mice (mg/kg): 1001, 1083 orally; 12.29, 14.97 i.v.; 300, 340 s.c.; LD50 in male, female rats (mg/kg): 1663, 1779 orally; 15.89, 15.70 i.v. (Sarafana) | |||||||||
NFPA 704 |
|
Ipratropium bromide Chemical Properties,Uses,Production
Chemical Properties
White Powder
Uses
Ipratropium Bromide is a nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
Definition
ChEBI: The anhydrous form of the bromide salt of ipratropium. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstru tive pulmonary disease and acute asthma.
General Description
Ipratropium bromide, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide (Atrovent), is a quaternaryammonium derivative of atropine. It is freely soluble inwater and ethanol but insoluble in chloroform and ether. Thesalt is stable in neutral and acidic solutions but rapidly hydrolyzedin alkaline solutions.
Biological Activity
Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.
Clinical Use
Ipratropium bromide is used in inhalation therapy toproduce dilation of bronchial smooth muscle for acute asthmaticattacks. The drug produces bronchodilation by competitiveinhibition of cholinergic receptors bound to smooth muscle of the bronchioles. Ipratropium may also act on thesurface of mast cells to inhibit ACh-enhanced release ofchemical mediators. The drug has a slow onset of action,within 5 to 15 minutes after being administered by inhalation,and should not be used alone for acute asthmatic attacks.The peak therapeutic effect from one dose is observedbetween 1 and 2 hours. The effects of the drug last for about6 hours. It has a half-life of 3.5 hours.
Ipratropium bromide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
AARTI INDUSTRIES LIMITED | 912267976666 | New Delhi, India | 172 | 58 | Inquiry |
J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
MELODY HEALTHCARE PVT LTD | +undefined2228780912 | Maharashtra, India | 20 | 58 | Inquiry |
Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
Navone Specialties (OPC) Pvt Ltd | +91-9323789882 +91-9323789882 | Maharashtra, India | 144 | 58 | Inquiry |
AARTI INDUSTRIES LTD | +91 22 6797 6666 | New Delhi, India | 32 | 58 | Inquiry |
Neuland Laboratories Limited | +91 (40) 2341-2934 | New Delhi, India | 24 | 50 | Inquiry |
Supplier | Advantage |
---|---|
AARTI INDUSTRIES LIMITED | 58 |
J S LABS | 58 |
Cipla Ltd | 58 |
Aarti Industries Limited (AIL) | 58 |
MELODY HEALTHCARE PVT LTD | 58 |
Ralington Pharma | 58 |
Humble Healthcare Limited | 58 |
Navone Specialties (OPC) Pvt Ltd | 58 |
AARTI INDUSTRIES LTD | 58 |
Neuland Laboratories Limited | 50 |
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