Nicergoline
- CAS No.
- 27848-84-6
- Chemical Name:
- Nicergoline
- Synonyms
- mne;Memoq;fi6714;TA 079;Ergotop;Sermion;Ergobel;CS-1354;Cergodum;nargoline
- CBNumber:
- CB9728301
- Molecular Formula:
- C24H26BrN3O3
- Molecular Weight:
- 484.39
- MOL File:
- 27848-84-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/17 8:48:38
| Melting point | 136-138° |
|---|---|
| Boiling point | 594.4±50.0 °C(Predicted) |
| Density | 1.3558 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Practically insoluble in water, freely soluble in methylene chloride, soluble in ethanol (96 per cent). |
| form | Solid |
| pka | 6.33±0.40(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble in alcohol, chloroform, and acetone. Insoluble in water. |
| Merck | 14,9496 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KE6341000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29396100 | |||||||||
| Toxicity | LD50 in male mice, rats (mg/kg): 860, 2800 orally; 46, 43 i.v. (Neumann, Lauschner) | |||||||||
| NFPA 704 |
|
Nicergoline price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N7889 | Nicergoline analytical standard, for drug analysis | 27848-84-6 | 100MG | ₹4275.88 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0904 | Nicergoline | 27848-84-6 | 100MG | ₹3000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0904 | Nicergoline | 27848-84-6 | 1G | ₹15200 | 2022-05-26 | Buy |
Nicergoline Chemical Properties,Uses,Production
Chemical Properties
Fine to granular, white or yellowish powder.
Uses
Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
Biological Activity
α -adrenergic, vasodilator. Cognitive enhancer.
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. A vasodilator. When heated to decomposition it emits very toxic fumes of Brand NOx.
Nicergoline Preparation Products And Raw materials
Global( 367)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Venkatasai Life Sciences | +91-9908134868 +91-8008303069 | Hyderabad, India | 186 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 946 | 58 | Inquiry |
| Aaditya Pharmachem | 91-8037401177 | Maharashtra, India | 9 | 58 | Inquiry |
| Venkatasai Life Sciences | 91-40-23076623 | Hyderabad, India | 12 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
Related articles
- Uses and side effects of Nicergoline
- Nicergoline is an ergot derivative that may protect againstdegeneration of cholinergic neurones.
- May 6，2022
27848-84-6(Nicergoline)Related Search:
chevron_left
1of4
chevron_right
10-methoxy-1,6-dimethyl-ergoline-8-beta-methano5-bromo-3-pyridinecarboxy
10-methoxy-1,6-dimethyl-ergoline-8-beta-methano5-bromonicotinate(ester)
10-methoxy-1,6-dimethylergoline-8-methanol5-bromo-3-pyrindinecarboxylate(es
1-methyl-lumilysergol8-(5-bromonicotinate)10-methylether
8-beta-((5-bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
fi6714
late(ester)
mne
nargoline
nicergolin
nicotergoline
nimergoline
NICERGOLINE
Ergotop
Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
Memoq
Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8b-yl)methyl ester (8CI)
NSC 150531
Sermion
TA 079
(8β)-10-methoxy-1,6-dimethylergoline-8-methanol5-bromo-3-pyridinecarboxylateester
10a-Methoxy-9,10-dihydrolyzergol (MDL)
1-Methyl-10a-Methoxy-9,10-dihydrolyzergol (1-MMDL)
[(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-Bromopyridine-3-carboxylate
5-Bromopyridine-3-carboxylic Acid [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl Ester
((6aR,9R,10aS)-10a-Methoxy-4,7-diMethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)Methyl 5-broMonicotinate
Ergoline-8-Methanol,10-Methoxy-1,6-diMethyl-, 8-(5-broMo-3-pyridinecarboxylate), (8b)-
Nicergoline for system suitability
Nicergoline for peak identification
nicergoline Fr.P
10-Methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinate
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8.beta.)-
1,6-Dimethyl-8b-(5-bromonicotinoyloxymethyl)-10a-methoxyergoline
Cergodum
Circo-Maren
Dilasenil
Duracebrol
Ergobel
Ergoline-8b-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8b)- (9CI)
5-BROMONICOTINIC ACID 10-METHOXY-1,6-DIMETHYLERGOLINE-8-METHANOL ESTER
5-BROMONICOTINIC ACID 10-METHOXY-1,6-DIMETHYLERGOLINE-8-METHYL ESTER
(8BETA)-10-METHOXY-1,6-DIMETHYLERGOLINE-8-METHANOL 5-BROMO-3-PYRIDINE CARBOXYLATE ESTER
(+)-10-methoxy-1,6-dimethylergoline-8-beta-methanol5-bromonicotinate
10-methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
Nicergoline powder
CS-1354
Nicergoline, Sermion
API-Nicergoline
Nicergoline CRS
Nicergoline for peak identification CRS
Nicergoline>
Nicergoline for system suitability CRS
Nicergolinum
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-,5-bromo-3-pyridinecarboxylate (ester), (8b)-
((6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-chloronicotinate
(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
Nicergoline impurity