Darifenacin hydrobromide
- CAS No.
- 133099-07-7
- Chemical Name:
- Darifenacin hydrobromide
- Synonyms
- Emsele;Enablex;Emselex;UK 88525-04;Darifenacin HCl;DARIFENACIN HBR;Darifenacin hydrobro;DARFENACIN HYDROBROMIDE;Darifenacin Hydrobromid;darifenacin hydrobromide
- CBNumber:
- CB9855171
- Molecular Formula:
- C28H31BrN2O2
- Molecular Weight:
- 507.47
- MOL File:
- 133099-07-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/11 15:49:39
| Melting point | 228-2300C |
|---|---|
| alpha | 25D -30.3° (c = 1.0 in methylene chloride) |
| storage temp. | -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +41 to +49°, c = 1 in methylene chloride |
| CAS DataBase Reference | 133099-07-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934990002 | |||||||||
| NFPA 704 |
|
Darifenacin hydrobromide price More Price(2)
Darifenacin hydrobromide Chemical Properties,Uses,Production
Description
Darifenacin, an orally active, once a day selective M3 receptor antagonist, was launched for the treatment of overactive bladder in patients with symptoms of urge urinary incontinence, urgency and frequency. The drug selectively inhibits M3 receptor in the detrusor muscle while sparing the M1 and M2 receptors that are believed to be involved in central nervous system and cardiovascular function respectively. The compound was originally developed by Pfizer and licensed to Novartis and Bayer.
Chemical Properties
White Solid
Uses
Darifenacin hydrobromide is used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.
Definition
ChEBI: The hydrobromide salt of darifenacin. A selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, it is used in the management of urinary incontinence.
General Description
Darfenacin (Enablex),(s)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphen-ylacetamide, is an antimuscarinicagent that has selectivity for the M3 muscarinicsubtype receptor. By competitively blocking of the muscarinicreceptors results in a reduction of the smoothmuscle tone, allowing for greater volume of urine to bestored in the bladder. This results in less urinary incontinence,urgency, and frequency. It is a white to almostwhite, crystalline powder, with a molecular weight of507.5. Darifenacin is metabolized by the isozymesCYP2D6 and CYP3A4 with the primary metabolic routesbeing monohydroxylation of the dihydrobenzofuran ring,opening of the dihydrobenzofuran ring, and N-dealkylationof the pyrrolidine nitrogen.
Darifenacin hydrobromide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Lee Pharma Ltd | +91-9849085929 +91-9849085929 | Hyderabad, India | 42 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Megafine Pharma | +91 9867686666, +91 9665458868 | Maharashtra, India | 29 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Unimark Remedies Ltd | +91-2267304120 +91-2267304120 | Maharashtra, India | 48 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Apotex Pharmachem India Pvt Ltd | 58 |
| Cipla Ltd | 58 |
| Alembic Pharmaceuticals Limited | 58 |
| Hetero Drugs Limited | 58 |
| Macleods Pharmaceuticals Limited | 58 |
| Lee Pharma Ltd | 58 |
| HRV Global Life Sciences | 58 |
| Megafine Pharma | 58 |
| Ralington Pharma | 58 |
| Unimark Remedies Ltd | 58 |
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