젬투주맙

젬투주맙 C화학적 특성, 용도, 생산

개요

Gemtuzumab ozogamicin was launched as the first antibody-targeted antineoplastic agent for treatment of patients with acute myeloid leukemia (AML). This immunoconjugate consists of an anti-CD33 humanized mouse monoclonat antibody (lgG4) linked via a bifunctional linker to the cytotoxic antibiotic calicheamicin. Once, the anti-CD33 binds to its antigen expressed on AML blast cells, a complex forms that is internalized, eventually releasing the calicheamicin derivative inside the cell. The released antibiotic binds to the minor groove of DNA and after Bergman cyclization induces double-strand breaks and cell-death. Results from both phase I and II clinical trials suggested that this drug, when administered (9 mg/m2 as 2 i.v. infusions separated by 14 days) as a single agent to patients in first relapse, demonstrates an acceptable safety profile, while achieving meaningful clinical remission in 32 to 43% of individuals. Gemtuzumab ozogamicin is considered at least as effective as conventional therapy but presents a more favorable tolerability profile as compared to standard chemo-therapeutic drugs commonly used to treat AML. This agent received accelerated approval from the FDA for the treatment of patients in first relapse who are 60 years of age or older and who are not considered candidates for cytotoxic chemotherapy.

용도

Treatment of relapsed, acute myelogenous leukemia (cytotoxic calicheamicin derivative conjugated to a humanized monoclonal antibody).

일반 설명

Gemtuzumab ozogamicin (Mylotarg, fusion molecule) isan MAb derived from the CD33 antigen, a sialic aciddependentadhesion protein expressed on the surface ofleukemia blasts and immature normal cells of myelomonocyticorigin but not on normal hematopoietic stem cells. Gemtuzumab ozogamicin is indicated for the treatmentof patients with CD33-positive acute myeloid leukemia infirst relapse among adults 60 years of age or older who arenot considered candidates for cytotoxic chemotherapy.Gemtuzumab ozogamicin binds to the CD33 antigen expressedby hematopoietic cells. This antigen is expressed onthe surface of leukemic blasts in more than 80% of patientswith acute myeloid leukemia. CD33 is also expressed onnormal and leukemic myeloid colony-forming cells, includingleukemic clonogenic precursors, but it is not expressedon pluripotent hematopoietic stem cells or nonhematopoieticcells. Binding of the anti-CD33 antibody results in acomplex that is internalized. On internalization thecalicheamicin derivative is released inside the lysosomes ofthe myeloid cells. The released calicheamicin derivativebinds to the minor groove of DNA and causes double-strandbreaks and cell death.

젬투주맙 준비 용품 및 원자재

원자재

준비 용품

젬투주맙 공급 업체

공급자	전화	이메일	국가	제품 수	이점
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50000	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Alchemist-pharm chemical Technology Co. Ltd.	0371-67991738 13783628208	carl@alchemist-pharm.com	China	1877	58
Wuhan Chemstan Biotechnology Co., Ltd.	027-65317797 15926423062	422450190@qq.com	China	10351	58
Hubei Kele Fine Chemical Co., Ltd	027-59101668 19945030958	2881924765@qq.com	China	7969	58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.	+86-027-59232304 15387063101	2881924050@qq.com	China	9938	58

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