2-히드록시벤조니트릴

2-히드록시벤조니트릴
2-히드록시벤조니트릴 구조식 이미지
카스 번호:
611-20-1
한글명:
2-히드록시벤조니트릴
동의어(한글):
2-사이아노페놀;2-히드록시벤조니트릴
상품명:
2-Cyanophenol
동의어(영문):
2-HYDROXYBENZONITRILE;CYANOPHENOL;O-CYANOPHENOL;Salicylnitrile;TIMTEC-BB SBB007959;2-Cyanopheno;2-CYANOPHENOL;SALICYLONITRILE;2 /4 CyanoPhenol;2-Cyanophenol,99%
CBNumber:
CB9305904
분자식:
C7H5NO
포뮬러 무게:
119.12
MOL 파일:
611-20-1.mol
MSDS 파일:
SDS

2-히드록시벤조니트릴 속성

녹는점
92-95 °C (lit.)
끓는 점
149 °C/14 mmHg (lit.)
밀도
1.1052
증기압
0.17Pa at 25℃
굴절률
1.5372
인화점
149°C/14mm
저장 조건
Inert atmosphere,Room Temperature
용해도
클로로포름(소량으로 용해), 메탄올(약간 용해됨)
물리적 상태
결정성 분말
산도 계수 (pKa)
6.86(at 25℃)
색상
황백색에서 갈색까지
수용성
녹는
BRN
1210029
안정성
안정적인. 강한 산화제, 강한 염기와 호환되지 않습니다.
LogP
1.66 at 30℃
CAS 데이터베이스
611-20-1(CAS DataBase Reference)
NIST
Benzonitrile, 2-hydroxy-(611-20-1)
EPA
Benzonitrile, 2-hydroxy- (611-20-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36/37/38-20/21/22
안전지침서 26-36-45
WGK 독일 3
위험 참고 사항 Irritant
TSCA Yes
HS 번호 29269095
기존화학 물질 2015-3-6324
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 GHS hazard pictograms P280, P305+P351+P338, P310
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
NFPA 704
0
2 0

2-히드록시벤조니트릴 MSDS


2-Cyanophenol

2-히드록시벤조니트릴 C화학적 특성, 용도, 생산

개요

Cyanophenol is a vital molecule widely used to synthesize liquid crystal materials, medicines, spices, pesticides, corrosion inhibitors, etc. Cyanophenol is formed by substituting two hydrogen atoms of benzene molecules with hydroxyl and cyano groups, respectively. The cyano and hydroxyl groups are in the ring plane in the stable molecular structure. The hydroxyl group can have two different orientations relative to the cyano group. 2-cyanophenol, one of the Cyanophenol, is an essential ingredient in pesticides, spices, liquid crystal materials, etc. It is an especially critical intermediate for synthesizing methoxyacrylate fungicide mystrostrobin, widely used in agrochemicals, pharmaceutical chemicals, and other industries. The cyano group can strongly attract electrons. Replacing a hydrogen atom of the benzene ring by the cyano group usually increases the ionization energy (IE)[1].

화학적 성질

2-Cyanophenol is a white to light yellow crystal powder with a pungent and bitter odor. It is partially soluble in water with a Pka value of 7.17. However, it is unstable when exposed to strong alkalis and oxidants. It is an important intermediate for the synthesis of the fungicide azoxystrobin and the antihypertensive drug Bunirolol.

용도

2-Hydroxybenzonitrile is used as starting reagent during the synthesis of mono-alkoxyphenyloxazoline, furanoside.

주요 응용

2-Cyanophenol is used in the synthesis of CDK/GSK-3 inhibitors, for usage as therapeutics in Alzheimer's disease (AD).

Synthesis

2-Hydroxybenzonitrile can be synthesized by condensing salicylaldehyde with hydroxylamine hydrochloride to produce salicylaldoxime. Then, the salicylaldoxime is reacted with acetic anhydride followed by hydrolysis to yield 2-Hydroxybenzonitrile.
Process for the preparation of 2-hydroxybenzonitrile

저장

Store at 2°C - 8°C, close container well, protect from light.                                   

2-히드록시벤조니트릴 준비 용품 및 원자재

원자재

준비 용품


2-히드록시벤조니트릴 공급 업체

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