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1-(3-Chlorphenyl)piperazine
1-(3-Chlorphenyl)piperazine
- CAS:
- 6640-24-0
- MF:
- C10H13ClN2
- MW:
- 196.68
Properties
- Melting point:
- 210-214°C
- Boiling point:
- 105 °C
- Density
- 1.193
- refractive index
- 1,598-1,600
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), Methanol (Sparingly)
- form
- Oil
- pka
- 8.85±0.10(Predicted)
- color
- Colourless to Orange
- LogP
- 2.468
Safety Information
- Symbol(GHS)
GHS09
- Hazard statements
- H411
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36
- HazardClass
- IRRITANT
- HS Code
- 29339900
Use
It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
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