1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
- CAS:
- 28289-54-5
- MF:
- C12H15N
- MW:
- 173.25
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Properties
- Melting point:
- aprox. 36°C
- Boiling point:
- 128-132 °C12 mm Hg(lit.)
- Density
- 1.001±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 8.66±0.40(Predicted)
- color
- Pale Yellow to Light Yellow
- Merck
- 13,6319
- Stability:
- Stable. Incompatible with strong oxidizing agents.
Safety Information
- Symbol(GHS)
GHS08,GHS06
- Signal word
- Danger
- Hazard statements
- H370-H301
- Precautionary statements
- P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501
- Hazard Codes
- T
- Risk Statements
- 25-39/23/24/25
- Safety Statements
- 45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- UT8358900
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.
Use
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
0 India supplier list of "1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE"
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- Product Name:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Products Intro:Brand:pharmaffiliates | Product Number:PA1685020
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name: 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
- Products Intro:Purity: 99% | Package: 1g;1USD
- Company Type: Trader
- Country/Region: CHINA
$1.00/ 1g
- Product Name:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base
- Products Intro:Purity: 98% | Package: $332.9/25mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies