Flumethasone manufacturers and suppliers in india

Flumethasone

Properties

Melting point:: 237-240°C

Boiling point:: 569.8±50.0 °C(Predicted)

Density: 1.1621 (estimate)

storage temp.: 2-8°C

solubility: acetic acid: soluble10mg/mL

form: solid

pka: 11.98±0.70(Predicted)

color: white

optical activity: [α]25/D 67.0 to 71.0°, c = 1 in dioxane

Water Solubility: 1mg/L(20 ºC)

Merck: 14,4138

InChIKey: WXURHACBFYSXBI-GQKYHHCASA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H351

Precautionary statements: P281

Hazard Codes: Xn

Risk Statements: 40

Safety Statements: 22-36

WGK Germany: 3

RTECS: TU3832000

HS Code: 29144000

Use

Flumethasone is an anti-inflammatory glucocorticoid used in veterinary practice and used as an anti-inflammatory for a variety of animals. It is commonly investigated for its effectiveness in animals to combat inflammatory symptoms caused by pathogens and to better understand inflammatory mechanisms. It is also used as to investigate novel techniques that detect and quantify steroid compounds within muscles. For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions. Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity. Flumethasone has been shown to exert anti-inflammtory effects by functioning as a glucocorticoid receptor agonist. Stimulating this receptor promotes inhibition of phospholipase A2 activity. This enzyme catalyzes arachidonic acid into eicosanoids most of which stimulate anti-inflammation mechanisms.