Lomefloxacin hydrochloride manufacturers and suppliers in india

Lomefloxacin hydrochloride

Properties

Melting point:: 290-3000C

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: 1 M NaOH: soluble50mg/mL

form: powder to crystal

color: white to off-white

Merck: 14,5562

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H317

Precautionary statements: P261-P264-P270-P272-P280-P301+P312+P330-P302+P352+P333+P313+P363-P501

Hazard Codes: Xn

Risk Statements: 22

WGK Germany: 3

RTECS: VB1997500

HS Code: 29339900

Use

Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.