Lomefloxacin hydrochloride
- CAS No.
- 98079-52-8
- Chemical Name:
- Lomefloxacin hydrochloride
- Synonyms
- LOMEFLOXACIN HCL;1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride;ny198;omefL;Okacyn;Okacin;bareon;Chimono;Uniquin;LoMflox
- CBNumber:
- CB5723616
- Molecular Formula:
- C17H20ClF2N3O3
- Molecular Weight:
- 387.81
- MOL File:
- 98079-52-8.mol
- Modify Date:
- 2024/4/15 18:41:30
| Melting point | 290-3000C |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | 1 M NaOH: soluble50mg/mL |
| form | powder to crystal |
| color | white to off-white |
| Merck | 14,5562 |
| CAS DataBase Reference | 98079-52-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P261-P264-P270-P272-P280-P301+P312+P330-P302+P352+P333+P313+P363-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VB1997500 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Lomefloxacin hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L2906 | Lomefloxacin hydrochloride | 98079-52-8 | 1G | ₹5748.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L2906 | Lomefloxacin hydrochloride | 98079-52-8 | 10G | ₹32583.25 | 2022-06-14 | Buy |
| TCI Chemicals (India) | L0216 | Lomefloxacin Hydrochloride | 98079-52-8 | 5G | ₹6500 | 2022-05-26 | Buy |
| SRL | 52737 | Lomefloxacin Hydrochloride (LMF), 98.5% | 98079-52-8 | 1Gms | ₹1260 | 2022-05-26 | Buy |
| SRL | 52737 | Lomefloxacin Hydrochloride (LMF), 98.5% | 98079-52-8 | 5Gms | ₹3260 | 2022-05-26 | Buy |
Lomefloxacin hydrochloride Chemical Properties,Uses,Production
Description
Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.
Chemical Properties
White powder with no smell, bitter taste
Uses
Fluorinated quinolone antibacterial. DNA gyrase antagonist
Definition
ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for he treatment of otitis externa and otitis media.
References
Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.
Lomefloxacin hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Nakoda Chemicals Ltd | +91-9848218200 +91-9848218200 | Telangana, India | 15 | 58 | Inquiry |
| Turtle Pharma Private Limited | +91-9850998504 +91-9850998504 | Maharashtra, India | 27 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Beaukev Pharma International Private Limited | 91-22-49744827 | Maharashtra, India | 34 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| PANCHSHEEL ORGANICS LTD | 58 |
| Ralington Pharma | 58 |
| Nakoda Chemicals Ltd | 58 |
| Turtle Pharma Private Limited | 58 |
| Hetero Drugs Limited | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| Clearsynth Labs | 58 |
| Beaukev Pharma International Private Limited | 58 |
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