Lynestrenol manufacturers and suppliers in india

Lynestrenol

Properties

Melting point:: 158°C

alpha: D -13° (chloroform)

Boiling point:: 366.92°C (rough estimate)

Density: 1.0083 (rough estimate)

refractive index: 1.4500 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).

pka: 13.12±0.40(Predicted)

form: Solid

color: Crystals from MeOH

Merck: 14,5629

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H351-H361

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

RTECS: RC8964300

HS Code: 2937230000

Use

Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)