TMC-207 manufacturers and suppliers in india

TMC-207

Properties

Melting point:: 104 °C

Boiling point:: 702.7±60.0 °C(Predicted)

Density: 1.322±0.06 g/cm3(Predicted)

storage temp.: Room temperature

solubility: Soluble in DMSO (10 mg/ml)

form: solid

pka: 13.05±0.29(Predicted)

color: White

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS08,GHS09,GHS06

Signal word: Danger

Hazard statements: H400-H373-H301-H410

Precautionary statements: P273-P391-P501-P264-P270-P301+P310-P321-P330-P405-P501-P273-P391-P501-P260-P314-P501

HS Code: 2933499090

Use

Bedaquiline (also known as TMC207 and R207910) is a diarylquinoline that was discovered from a high-throughput, whole-cell screening strategy with Mycobacterium smegmatis used as a surrogate for M. tuberculosis. Bedaquiline is a single enantiomer of an initial screening hit. Bedaquiline has potent and selective activity against mycobacteria, and is active against both drug-sensitive and drug-resistant M. tuberculosis. The mechanism of action of bedaquiline is unique amongst anti-TB drugs and involves inhibition of mycobacterial ATP synthase; it is not active against human ATP synthase. Bedaquiline has in vivo activity in numerous preclinical models of TB infection, alone and in combination with other anti-TB agents, and has bactericidal activity in established TB infection models.