Topotecan
Topotecan
- CAS:
- 123948-87-8
- MF:
- C23H23N3O5
- MW:
- 421.45
Suppliers by country/region
Company Type
Properties
- Melting point:
- −114 °C(lit.)
- Boiling point:
- >100 °C(lit.)
- Density
- 1.2 g/mL at 25 °C(lit.)
- vapor density
- 1.3 (vs air)
- vapor pressure
- 613 psi ( 21.1 °C)
- Flash point:
- 12 °C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- H2O: soluble
- form
- liquid
- pka
- 8.92±0.40(Predicted)
- color
- yellow
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H340-H361d
- Precautionary statements
- P201-P202-P280-P308+P313-P405-P501
- Hazard Codes
- T,C,F,Xi
- Risk Statements
- 36/37/38-67-35-20-11-34-48-46-36
- Safety Statements
- 26-45-36/37/39-37/39-36-22-24/25-16-7
- RIDADR
- UN 3286 3/PG 2
- WGK Germany
- 2
- RTECS
- MW4025000
- F
- 3
- HazardClass
- 8
- PackingGroup
- II
Use
Topotecan was launched in the US for the second-line treatment of ovarian cancer. It can be prepared in four steps from camptothecin and is a water soluble derivative of the natural product with decreased toxicity. Unlike its chemical relative irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks. When the replication fork reaches this complex, double-stand breaks can occur. This signals apoptosis and eventually gives rise to cell death. Evidence indicates hycamtin is safe for people with impaired hepatic function.
7 India supplier list of "Topotecan"
- Product Name:Hydrochloricacidin2-propanol
- Products Intro:Brand:sigma aldrich | Product Number:1.00326 | Purity:acc.toDIN51558part1c(HCl)=0.1mol/l(0,1N),Titripur?
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Topotecan
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.085928
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Topotecan
- Products Intro:Brand:clearsynth | Product Number:CS-O-02414
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Hydrogen chloride gas
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Muriatic Acid
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:(S)-Topotecan
- Products Intro:Brand:pharmaffiliates | Product Number:PA2042560
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Topotecan
- Products Intro:Brand:ajchemicals | Product Number:JDH-38031 | Purity:98+%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Hydrogen Chloride Gas
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Hydrogen Chloride Gas
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Hydrogen Chloride Gas
- Company Type: Reagent
- Country/Region: INDIA