Cabozantinib
Cabozantinib
- CAS:
- 849217-68-1
- MF:
- C28H24FN3O5
- MW:
- 501.51
Suppliers by country/region
Company Type
Properties
- Melting point:
- 212-215°C
- Boiling point:
- 758.1±60.0 °C(Predicted)
- Density
- 1.396
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- form
- White powder.
- pka
- 13.86±0.70(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- ONIQOQHATWINJY-UHFFFAOYSA-N
- SMILES
- C1(C(NC2=CC=C(OC3C4C(N=CC=3)=CC(OC)=C(OC)C=4)C=C2)=O)(C(NC2=CC=C(F)C=C2)=O)CC1
Safety Information
- Symbol(GHS)
GHS05
- Signal word
- Danger
- Hazard statements
- H315-H318
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310
Use
In clinical trials, common adverse effects caused by cabozantinib include diarrhea, stomatitis, palmar-plantarrythrodysesthesia syndrome (PPES), and loss of weight, loss of appetite, nausea, fatigue, oral pain, taste disorders, high blood pressure, abdominal pain and constipation. The most common laboratory abnormalities ( 25%) were increased aspartate aminotransferase, alanine aminotransferase, lymphopenia, increased alkaline phosphatase level, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia and hyperbilirubinemia. For patients receiving cabozantinib, 57% of patients have gotten increased level of thyroid stimulating hormone after initial dose, compared with patients receiving placebo, increased by 19%. Information regarding to the anticancer drug, mechanism of action, pharmacokinetics, side effects, and drug interactions of cabozantinib were compiled and edited by Yan Shi from Chemicalbook. (2015-10-23)
6 India supplier list of "Cabozantinib"
- Product Name:Cabozantinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Tamil Nadu,INDIA
- Product Name:Cabozantinib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Cabozantinib >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089168
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Cabozantinib
- Products Intro:Brand:synzeal | Product Number:203010933
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:CabozantinibD4
- Products Intro:Brand:clearsynth | Product Number:CS-AP-00013
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Cabozantinib
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Cabozantinib
- Products Intro:Brand:pharmaffiliates | Product Number:PA3062000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Cabozantinib
- Company Type: Reagent
- Country/Region: Karnataka,INDIA
- Product Name:Cabozantinib
- Company Type: Reagent
- Country/Region: Pune,INDIA
- Product Name:Cabozantinib
- Products Intro:Brand:ajchemicals | Product Number:JDH-27451 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA