Dabrafenib
Dabrafenib
- CAS:
- 1195765-45-7
- MF:
- C23H20F3N5O2S2
- MW:
- 519.56
Suppliers by country/region
Company Type
Properties
- Melting point:
- 214-216oC
- Boiling point:
- 653.7±65.0 °C(Predicted)
- Density
- 1.443
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).
- form
- White solid.
- pka
- 6.62±0.10(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- BFSMGDJOXZAERB-UHFFFAOYSA-N
- SMILES
- C1(S(NC2=CC=CC(C3=C(C4C=CN=C(N)N=4)SC(C(C)(C)C)=N3)=C2F)(=O)=O)=C(F)C=CC=C1F
Safety Information
- Symbol(GHS)
GHS08,GHS09
- Signal word
- Warning
- Hazard statements
- H361-H411-H400
- Precautionary statements
- P273-P391-P501-P201-P202-P281-P308+P313-P405-P501
- HS Code
- 29350090
Use
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide is well known as dabrafenib. It is a drug for the treatment of cancers associated with a mutated version of the gene BRAF. Dabrafenib acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth. Dabrafenib has clinical activity with a manageable safety profile in clinical trials of phase-I and -II in patients with BRAF(V600)-mutated metastatic melanoma1,2. Its mechanism of action is acted as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 2B6 Inducer, and Cytochrome P450 2C8 Inducer, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer, and Organic Anion Transporting Polypeptide 1B1 Inhibitor, and Organic Anion Transporting Polypeptide 1B3 Inhibitor, and Organic Anion Transporter 1 Inhibitor, and Organic Anion Transporter 3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor3,4. It is not indicated for the treatment of patients with wild-type BRAF melanoma or wild-type BRAF NSCLC. MEKINIST is not indicated for the treatment of patients with melanoma who have progressed on prior BRAF-inhibitor therapy5.
6 India supplier list of "Dabrafenib"
- Product Name:Dabrafenib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Dabrafenib
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dabrafenib
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dabrafenib
- Products Intro:Purity: 99% | Package: 1kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Dabrafenib
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Dabrafenib
- Products Intro:Brand:pharmaffiliates | Product Number:PA3106000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Dabrafenib free base
- Products Intro:Purity: 99.9% | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
$0.00/ 1kg