CORTICOSTERONE
CORTICOSTERONE
- CAS:
- 50-22-6
- MF:
- C21H30O4
- MW:
- 346.47
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Properties
- Melting point:
- 179-183 °C(lit.)
- alpha
- D15 +223° (c = 1.1 in alc)
- Boiling point:
- 401.19°C (rough estimate)
- Density
- 1.0413 (rough estimate)
- refractive index
- 1.4430 (estimate)
- Flash point:
- 9℃
- storage temp.
- -20°C
- solubility
- Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated)
- form
- White to tan crystalline powder
- color
- White to Pale Yellow
- optical activity
- [α]20/D +223±3°, c = 1% in ethanol
- Water Solubility
- 240.5mg/L(37 ºC)
- Merck
- 2538
- BRN
- 2339601
- Stability:
- Stable, but light sensitive. Incompatible with strong oxidizing agents.
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- H302+H312+H332-H351
- Precautionary statements
- P202-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313
- Hazard Codes
- Xi,N,Xn,T,F
- Risk Statements
- 43-40-39/23/24/25-23/24/25-11
- Safety Statements
- 36-22-45-36/37-16
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
- RTECS
- GM7650000
- HS Code
- 29372900
- Toxicity
- An adrenocortical steroid with modest glucocorticoid and mineralocorticoid activity. It is the primary glucocorticoid in the rat.
Use
Purify corticosterone by recrystallisation from Me2CO (trigonal plates), EtOH or isoPrOH. It has UV max at 240nm, and gives an orange-yellow solution with strong fluorescence on treatment with concentrated H2SO4. It is insoluble in H2O but soluble in organic solvents. [Reichstein Mason et al. J Biol Chem 114 613 1936; ORD: Foltz et al. J Am Chem Soc 7 7 4359 1955; NMR: Shoolery & Rogers J Am Chem Soc 8 0 5121 1958.] The 21-O-acetyl derivative [1173-26-8] crystallises from Me2CO/Et2O with m 152.5-153o, [] D 20 +195o (c 0.6, Me2CO), and the 21-O-benzoyl derivative crystallises from AcOH/Et2O with m 201-202o [Reichstein Helv Chim Acta 2 0 953 1937]. [Beilstein 8 IV 2907.]
5 India supplier list of "CORTICOSTERONE"
- Product Name:Corticosterone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Corticosterone
- Products Intro:Brand:synzeal | Product Number:394819481
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Corticosterone-CAS50-22-6-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:235135 | Purity:Corticosteroidhormonesynthesizedinresponsetostress.
- Company Type: Trader
- Country/Region: INDIA
- Product Name:CORTICOSTERONE
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:CORTICOSTERONE
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:CORTICOSTERONE
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:CORTICOSTERONE
- Company Type: Reagent
- Country/Region: INDIA