CYTOCHALASIN B manufacturers and suppliers in india

CYTOCHALASIN B

Properties

Melting point:: 218-223 °C

Boiling point:: 577.96°C (rough estimate)

Density: 1.1490 (rough estimate)

refractive index: 1.6290 (estimate)

Flash point:: 85℃

storage temp.: -20°C

solubility: ethanol: 20 mg/mL

form: powder

pka: 13.60±0.70(Predicted)

color: white

Merck: 13,2819

BRN: 1096207

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

InChIKey: UXVDBQLLXVKPRS-UZBFCAAUSA-N

LogP: 3.370

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H300+H310+H330-H361

Precautionary statements: P201-P202-P260-P280-P302+P352+P310-P304+P340+P310

Hazard Codes: T+,T

Risk Statements: 26/27/28-63-23/24/25

Safety Statements: 28-36/37-45

RIDADR: UN 1544 6.1/PG 2

WGK Germany: 3

RTECS: RO0205000

F: 10

HazardClass: 6.1(a)

PackingGroup: I

HS Code: 29349990

Toxicity: LD50 intraperitoneal in mouse: 30mg/kg

Use

Cytochalasin B is one of the most extensively studied members of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalasins, cytochalasin B exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of this class display diverse selectivity. However, lack of comparative co-metabolite analysis has restricted a more complete understanding of their individual selectivity.