Dicloxacillin manufacturers and suppliers in india

Dicloxacillin

Properties

Melting point:: 218 °C (decomp)

Boiling point:: 692.4±55.0 °C(Predicted)

Density: 1.62±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

pka: pKa 2.76(H2O t=37 I=0.15 (KCl)) (Uncertain)

Water Solubility: 3.63 mg/L

Safety Information

Use

Oral absorption: c. 50% Cmax , 250 mg oral: 9 mg/L after 1 h 500 mg intramuscular: 14–16 mg/L after 0.5–1 h Plasma half-life: 0.5 h Plasma protein binding: 95–97% Absorption Absorption in the very young is poor and unpredictable. Metabolism and excretion Dicloxacillin is partly metabolized in the liver and about 10% of the circulating drug is in the form of metabolites. Some 50–70% of a dose is excreted in the urine, about 20% as metabolites. It is eliminated both in the glomerular filtrate and by tubular secretion, and plasma concentrations are raised by probenecid. Parent drug and increased proportions of metabolites accumulate in renal failure. Elimination is increased through enhanced tubular secretion in patients with cystic fibrosis.