Clindamycin manufacturers and suppliers in india

Clindamycin

Properties

alpha: D +214° (chloroform)

Boiling point:: 134°C (rough estimate)

Density: 1.1184 (rough estimate)

refractive index: 1.6100 (estimate)

storage temp.: Store at -20°C

solubility: DMSO:52.5(Max Conc. mg/mL);123.54(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);70.59(Max Conc. mM)
Ethanol:52.5(Max Conc. mg/mL);123.54(Max Conc. mM)
PBS (pH 7.2):0.2(Max Conc. mg/mL);0.47(Max Conc. mM)

form: A crystalline solid

pka: 7.6(at 25℃)

color: White to light yellow

BCS Class: 1

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H362-H319

Precautionary statements: P201-P260-P263-P264-P270-P308+P313-P264-P280-P305+P351+P338-P337+P313P

Toxicity: LD50 subcutaneous in rat: 2618mg/kg

Use

Clindamycin is a semi-synthetic analogue of lincomycin, prepared by chloride substitution of the exocyclic sugar hydroxy group. This affords a more hydrophobic compound with improved pharmacodynamics. Like other members of the lincosamide family, clindamycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Clindamycin has been extensively studied with over 8,000 literature citations.