Minocycline hydrochloride manufacturers and suppliers in india

Minocycline hydrochloride

Properties

Melting point:: 205-210° (dec)

Boiling point:: 813℃

Flash point:: >110°(230°F)

storage temp.: 2-8°C

solubility: Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.

form: crystalline

color: yellow

Water Solubility: Freely soluble in water

Merck: 14,6202

Stability:: Light Sensitive

InChIKey: GLMUAFMGXXHGLU-VQAITOIOSA-N

SMILES: [C@@]12([H])C[C@@]3([H])C(C(=O)C4C(O)=CC=C(N(C)C)C=4C3)=C(O)[C@]1(O)C(=O)C(C(=O)N)=C(O)[C@H]2N(C)C.Cl |&1:0,3,21,31,r|

LogP: 0.808 (est)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H317-H360-H362-H303-H315-H319-H335

Precautionary statements: P201-P202-P260-P263-P264-P270-P272-P280-P302+P352+P333+P313+P363-P308+P313-P405-P501-P261-P280a-P304+P340-P305+P351+P338-P501a

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

RIDADR: 3249

WGK Germany: 3

RTECS: QI7630500

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29413020

Toxicity: human,TDLo,oral,14286ug/kg/10 (14.286mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEASKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE",Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994.

Use

Minocycline hydrochloride is a salt prepared from minocycline, taking advantage of the two basic dimethylamino groups which protonate and readily form a salt from hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.