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DIGOXIN
DIGOXIN
- CAS:
- 20830-75-5
- MF:
- C41H64O14
- MW:
- 780.95
Properties
- Melting point:
- 248 °C
- alpha
- 25Hg +13.4 to 13.8° (c = 10 in pyridine)
- Boiling point:
- 661.93°C (rough estimate)
- Density
- 1.1110 (rough estimate)
- refractive index
- 12 ° (C=10, Pyridine)
- Flash point:
- 9℃
- storage temp.
- Refrigerator
- solubility
- Soluble in dimethyl sulfoxide and methanol.
- form
- powder
- pka
- 13.50±0.70(Predicted)
- color
- White to Almost white
- Water Solubility
- 46.08mg/L(room temperature)
- Merck
- 14,3167
- BRN
- 77011
- BCS Class
- 1 (LogP), 3 (CLogP)
- LogP
- 1.260
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H300-H331-H373
- Precautionary statements
- P260-P264-P270-P301+P310-P304+P340+P311-P314
- Hazard Codes
- T,T+,F
- Risk Statements
- 25-26/27/28-23/25-39/23/24/25-23/24/25-11-28-26
- Safety Statements
- 22-36/37/39-45-36/37-16-28A
- RIDADR
- UN 3462 6.1/PG 2
- WGK Germany
- 3
- RTECS
- IH6125000
- F
- 3-10
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29389090
- Toxicity
- cat,LD50,oral,200ug/kg (0.2mg/kg),Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 1, 1966.
Use
Digoxin (Lanoxin) is a purified digitalis preparationfrom D. lanata and represents the most widely useddigitalis glycoside. This wide use is primarily a result of itsfast onset and short half-life. Position 3 of the steroid is substitutedwith three digitoxose residues that, when removed,provide a genin or aglycone steroid that is still capable of receptorbinding but with altered pharmacokinetics.
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