diloxanide manufacturers and suppliers in india

diloxanide

CAS:: 579-38-4

MF:: C9H9Cl2NO2

MW:: 234.08

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Properties

Melting point:: 175°

Boiling point:: 356.2±42.0 °C(Predicted)

Density: 1.439±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: DMSO:33.33(Max Conc. mg/mL);142.39(Max Conc. mM)

form: Solid

pka: 9.95±0.15(Predicted)

color: Light brown to brown

Safety Information

Use

Furamide, or eutamide, is the 2-furoate ester of 2,2-dichloro-4 -hydroxy-N-methylacetanilide. It was developed as a resultof the discovery that various α,α-dichloroacetamidespossessed amebicidal activity in vitro. Diloxanide itself andmany of its esters are also active, and drug metabolism studiesindicate that hydrolysis of the amide is required for theamebicidal effect. Nonpolar esters of diloxanide are morepotent than polar ones. Diloxanide furoate has been used inthe treatment of asymptomatic carriers of E. histolytica. Itseffectiveness against acute intestinal amebiasis or hepaticabscesses, however, has not been established. Diloxanidefuroate is a white crystalline powder. It is administered orallyonly as 500-mg tablets and may be obtained in the UnitedStates from the CDC in Atlanta, Georgia.