Dovitinib
Dovitinib
- CAS:
- 405169-16-6
- MF:
- C21H21FN6O
- MW:
- 392.43
Suppliers by country/region
Company Type
Properties
- Density
- 1.386
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 30 mg/ml).
- pka
- 9.44±0.70(Predicted)
- form
- solid
- color
- Yellow-green
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Use
Dovitinib is a receptor tyrosine kinase inhibitor that targets vascular endothelial growth factor-2, basic fibroblast growth factor-1, and platelet-derived growth factor β receptors (IC50s = 65, 11, and 5 nM, respectively). At 0.04 μM, dovitinib can inhibit endothelial cell proliferation and motility. These antiangiogenic effects have been proposed to be the mechanism by which dovitinib inhibits hepatocellular carcinoma growth and metastasis. Dovitinib has been evaluated in clinical trials for the treatment of advanced solid tumors. Dovitinib is a receptor tyrosine kinase inhibitor that targets vascular endothelial growth factor-2, basic fibroblast growth factor-1, and platelet-derived growth factor β receptors (IC50s = 65, 11, and 5 nM, respectively). At 0.04 μM, dovitinib can inhibit endothelial cell proliferation and motility. These antiangiogenic effects have been proposed to be the mechanism by which dovitinib inhibits hepatocellular carcinoma growth and metastasis. Dovitinib has been evaluated in clinical trials for the treatment of advanced solid tumors.
2 India supplier list of "Dovitinib"
- Product Name:Dovitinib 97%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.175054
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Dovitinib
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Dovitinib
- Products Intro:Brand:pharmaffiliates | Product Number:PA042460000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Dovitinib
- Products Intro:Brand:ajchemicals | Product Number:JDH-28598 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:CHIR-258(Dovitinib,TKI258)
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
- Products Intro:Purity: 99% | Package: 1kg;2USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
$2.00/ 1kg
- Product Name:Dovitinib
- Products Intro:Purity: > 95% | Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for Dovitinib.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:dovitinib
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:CHIR-258(Dovitinib,TKI258)
- Products Intro:Purity: 98% | Package: Package as requetsed
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Specialty chemical,UV Curing & Brightener,OLED Chemicals,CDMO SERVICES