Enflurane manufacturers and suppliers in india

Enflurane

Properties

Boiling point:: 56 °C

Density: 1.517

refractive index: 1.303

Flash point:: 56-57°C

storage temp.: 2-8°C

solubility: Chloroform (Soluble), DMSO (Sparingly), Dichloromethane (Sparingly), Methanol (S

form: Liquid

Specific Gravity: 1.517

color: Colorless to light yellow

Merck: 14,3581

BRN: 1737129

Exposure limits: TLV-TWA 570 mg/m³ (75 ppm) (ACGIH).

InChIKey: JPGQOUSTVILISH-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319

Precautionary statements: P264-P280-P305+P351+P338-P337+P313

Hazard Codes: F,T,Xi

Risk Statements: 36

Safety Statements: 23-26-36-39

RIDADR: UN 3334

OEL: Ceiling: 2 ppm (15.1 mg/m3) [60-minute] [*Note: REL for exposure to waste anesthetic gas.]

RTECS: KN6800000

Hazard Note: Flammable/Toxic

HS Code: 2909191800

Toxicity: LD50 oral in rat: 5450uL/kg

Use

Enflurane is a volatile liquid (bp＝56.5°C) with a blood:gas partition coefficient of 1.8 and an MAC of 1.68%.Approximately 2% to 8% of the drug is metabolized primarilyat the chlorofluoromethyl carbon. Little chlorofluoroaceticacid is produced suggesting minor metabolism at thedifluoromethyl carbon. Difluoromethoxydifluoroacetate andfluoride ion have been reported as metabolites. Enfluranemay increase heart rate, cause cardiac arrhythmias, increasecerebral blood flow, and increase intracranial pressure but allto a smaller degree than halothane. Enflurane also causeselectroencephalographic (EEG) patterns consistent withelectrical seizure activity. It has caused tonic–clonic convulsiveactivity in patients when used at high concentrations orduring profound hypocarbic periods. Enflurane is thereforenot recommended in patients with seizure disorders.