EQUISETIN
EQUISETIN
- CAS:
- 57749-43-6
- MF:
- C22H31NO4
- MW:
- 373.49
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Properties
- Melting point:
- 117-118 °C
- Boiling point:
- 556.0±50.0 °C(Predicted)
- Density
- 1.180±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.50±1.00(Predicted)
- color
- Pale Beige to Light Brown
- Stability:
- Hygroscopic
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P312-P260-P280
- HS Code
- 29339900
- Toxicity
- mouse,LD50,intraperitoneal,63mg/kg (63mg/kg),Antimicrobial Agents and Chemotherapy. Vol. 5, Pg. 634, 1974.
Use
The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer, as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core.
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