Etodolac
Etodolac
- CAS:
- 41340-25-4
- MF:
- C17H21NO3
- MW:
- 287.35
Suppliers by country/region
Company Type
Properties
- Melting point:
- 145-1480C
- Boiling point:
- 507.9±45.0 °C(Predicted)
- Density
- 1.193±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent)
- pka
- 4.65(at 25℃)
- form
- Solid
- color
- White to Orange to Green
- Water Solubility
- 40mg/L(37 ºC)
- Merck
- 14,3874
- BCS Class
- 2
- InChIKey
- NNYBQONXHNTVIJ-QGZVFWFLSA-N
- CAS DataBase Reference
- 41340-25-4(CAS DataBase Reference)
- EPA Substance Registry System
- Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro- (41340-25-4)
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301
- Precautionary statements
- P264-P270-P301+P310-P405-P501
- Hazard Codes
- T,Xi
- Risk Statements
- 23/24/25-40-36-25-36/37/38
- Safety Statements
- 22-36-45-26-36/37
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- UQ0360000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29349990
Use
Etodolac (Lodine, Ultradol), a chiral, COX-2 selectiveNSAID drug that is marketed as a racemate, possesses an indolering as the aryl portion of this group of NSAID drugs.It shares many similar properties of this group and is indicatedfor short- and long-term management of pain and OA.Similar to ketorolac, etodolac exhibits several uniqueenantioselective pharmacokinetic properties. For example,the “inactive” (R)-enantiomer has approximately a 10-foldhigher plasma concentration than the active (S)-enantiomer.Furthermore, the active (S)-enantiomer is less protein boundthan its (R)-enantiomer and therefore has a very large volumeof distribution. It is well absorbed with an elimination halflifeof 6 to 8 hours. Etodolac is extensively metabolized intothree major inactive metabolites, 6-hydroxy etodolac (via aromatichydroxylation), 7-hydroxy-etodolac (via aromatic hydroxylation),and 8-(1'-hydroxylethyl) etodolac (via benzylichydroxylation), which are eliminated as the correspondingether glucuronides. Its unstable, acyl glucuronide, however,is subject to enterohepatic circulation and reactivation tothe parent drug, similar to other NSAIDS in this class.
93 India supplier list of "Etodolac"
- Product Name:Etodolac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Uttar Pradesh,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:lodine
- Products Intro:Purity: 99% | Package: 25 KG
- Company Type: Trader
- Country/Region: Mumbai,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Etodolac
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Punjab,INDIA