Fludarabine manufacturers and suppliers in india

Fludarabine

Properties

Melting point:: 265-268°C

alpha: D25 +17 ±2.5° (c = 0.1 in ethanol)

Boiling point:: 747.3±70.0 °C(Predicted)

Density: 2.17±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMF: 20 mg/mL, clear, faintly yellow

form: Powder

pka: 13.05±0.70(Predicted)

color: White to Pale Yellow

Water Solubility: Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in water

Merck: 13,4152

BRN: 1225932

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChI: InChI=1/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/s3

InChIKey: HBUBKKRHXORPQB-VOSPVXAENA-N

SMILES: C12N=C(N=C(N)C=1N=CN2[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1)F |&1:10,11,13,15,r|

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H341-H361d

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

Hazard Codes: Xn

Risk Statements: 23/24/25-36/37/38-39/23/24/25-39-22

Safety Statements: 26-36/37-45-36

WGK Germany: 3

RTECS: AU6207000

F: 10

HS Code: 29349990

Use

Fludarabine is used to treat chronic lymphocyticleukemia and non-hodgkin's lymphoma. The mechanism ofaction involves the triphosphate metabolite and its inhibitionof dna chain elongation.Fludarabine phosphate is a purine antimetabolite approved for use in the management of patients with chronic lymphocytic leukemia.