Hydroxyzine manufacturers and suppliers in india

Hydroxyzine

Properties

Melting point:: 190°C

Boiling point:: 250 °C(Press: 0.1 Torr)

Density: 1.1020 (rough estimate)

refractive index: 1.5400 (estimate)

storage temp.: 2-8°C

solubility: Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly,

form: Oil to Gel

pka: pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate)

color: Colourless to Yellow

Water Solubility: < 700 mg/mL

BCS Class: 2

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H334-H372-H360-H336-H302

Precautionary statements: P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501-P260-P264-P270-P314-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501

Toxicity: LD50 oral in rat: 840mg/kg

Use

Hydroxyzine is used for the treatment of anxiety disorder as well as being used in other more serious cases as psychoneurosis. Therefore, it is prescribed as a means of regulating normal function. Hydroxyzine has shown to be as effective as the benzodiazepine drug bromazepam in the treatment of generalised anxiety disorder. A systematic review found that hydroxyzine is as excellent as other anxiolytic agents[benzodiazepines and buspirone] in efficacy, acceptability, and tolerability. Hydroxyzine can also be used for the treatment of allergic conditions including chronic urticaria, atopic or contact dermatoses, and histamine-mediated pruritus. Studies have found no adverse effects on the liver, blood, nervous system, or urinary tract.