Hydroxyzine
- CAS No.
- 68-88-2
- Chemical Name:
- Hydroxyzine
- Synonyms
- Atara;Atarox;Aterax;NP 212;Tran-Q;Atarax;Atazina;Deinait;UCB 492;Pamazone
- CBNumber:
- CB2547530
- Molecular Formula:
- C21H27ClN2O2
- Molecular Weight:
- 374.9
- MOL File:
- 68-88-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:54
| Melting point | 190°C |
|---|---|
| Boiling point | 250 °C(Press: 0.1 Torr) |
| Density | 1.1020 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly, |
| form | Oil to Gel |
| pka | pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate) |
| color | Colourless to Yellow |
| Water Solubility | < 700 mg/mL |
| BCS Class | 2 |
| NIST Chemistry Reference | Hydroxyzine base(68-88-2) |
| EPA Substance Registry System | Hydroxyzine (68-88-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H334-H372-H360-H336-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501-P260-P264-P270-P314-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501 | |||||||||
| Toxicity | LD50 oral in rat: 840mg/kg | |||||||||
| NFPA 704 |
|
Hydroxyzine Chemical Properties,Uses,Production
Description
Hydroxyzine is an antihistamine drug with M-cholinoblocking properties and expressed action on the CNS. It suppresses subcortical regions of the CNS including the limbic system and reticular formation. It potentiates the effect of narcotic analgesics and exhibits sedative effects.
Chemical Properties
Yellow Oil
Uses
Hydroxyzine is intended for the symptomatic treatment of anxiety and stress associated with neurosis as well as with conditions of organic illness. This drug has muscle relaxant, antihistimine, analgesic, local anesthetic, and antiemetic action as well as a wide therapeutic effect. It is mainly used in premedication and following general anesthesia, during which it potentiates the action of meperidine and barbiturates. It is frequently used in pediatrics as a mild sedative drug.
Indications
Drugs of choice for the treatment of dermatographism and cholinergic urticaria. They are also effective alone or in combination with other antihistamines in the management of acute and chronic urticaria, atopic and contact dermatoses, and histamine-induced pruritus. It may be used alone or with other antihistamines, and dosage should be pushed to the limit of tolerance or to subsidence of symptoms.
Definition
ChEBI: A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.
Hydroxyzine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Amco Crop Chemicals | 08048361230Ext 626 | Gujarat, India | 1 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Chemicea Pharmaceuticals Pvt Ltd | +91-9881765045/+91-8796656135 | Pune, India | 825 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21676 | 55 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
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